Evidence map›Paper›PMID 30949923›Full record

Observational studyCNS drugs2019

The Effect of Non-Gabapentinoid Anticonvulsants on Sensorimotor Recovery After Human Spinal Cord Injury.

Freda M Warner, Catherine R Jutzeler, Jacquelyn J Cragg, Bobo Tong, Lukas Grassner, Frank Bradke, Fred Geisler, John K Kramer

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in CNS drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Valproic Acid: A Potential Therapeutic for Spinal Cord Injury.Cellular and molecular neurobiology · 2021
    Review
  9. Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Freda M WarnerSchool of Kinesiology, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-8054-7476
Catherine R JutzelerSchool of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
Jacquelyn J CraggInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Blusson Spinal Cord Centre, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada.
Bobo TongInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Blusson Spinal Cord Centre, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada.
Lukas GrassnerDepartment of Neurosurgery and Center for Spinal Cord Injuries, Trauma Center Murnau, Murnau, Germany.
Frank BradkeAxon Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Fred GeislerDepartment of Medical Imaging, University of Saskatchewan, Saskatoon, SK, Canada.
John K KramerSchool of Kinesiology, University of British Columbia, Vancouver, BC, Canada. kramer@icord.org.
University of British Columbia · CAGerman Center for Neurodegenerative Diseases · DEInnsbruck Medical University · ATUniversity of Saskatchewan · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundRecent observational studies have shown an association between gabapentinoid anticonvulsants and greater motor recovery after spinal cord injury. There is preclinical evidence to suggest that other anticonvulsants, such as sodium channel blockers, may also confer beneficial effects. PURPOSE: The aim of the current study was to determine if non-gabapentinoid anticonvulsants were associated with neurological recovery after acute, traumatic spinal cord injury.

methodsThis was an observational cohort study using data from the Sygen clinical trial. The primary outcome was total motor score recovery in the first year after injury. Anticonvulsant use was extracted from concomitant medication records; individuals were classified based on early administration (within 30 days of injury), or late/no administration. Motor recovery was compared using linear mixed effects regression models with a drug-by-time interaction, and adjustment for confounders. A secondary analysis incorporated a propensity score matched cohort.

resultsOf the cohort (n = 570), 6% received anticonvulsants (carbamazepine, phenytoin, clonazepam, phenobarbital, and valproic acid) early after injury. After adjustments for initial injury level and severity, early exposure to non-gabapentinoid anticonvulsants was not associated with motor neurological outcomes (p = 0.38 for all anticonvulsants, p = 0.83 for sodium channel blockers, p = 0.82 in propensity-matched cohort).

conclusionNon-gabapentinoid anticonvulsant exposure was not associated with greater or lesser neurological recovery. This suggests that these medications, as administered for the acute management of spinal cord injury, do not impact long-term neurological outcomes.

Indexed as

AnticonvulsantsCohort StudiesEarly Medical InterventionHumansMotor ActivityRecovery of FunctionSpinal Cord InjuriesTrauma Severity IndicesTreatment OutcomeAnticonvulsants

Identifiers

PMID30949923
OpenAlexW2928038989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.