Evidence map›Paper›PMID 30949921›Full record

ReviewCurrent nutrition reports2019

Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease.

Andrea M McGrattan, Bernadette McGuinness, Michelle C McKinley, Frank Kee, Peter Passmore, Jayne V Woodside, Claire T McEvoy

Open access · hybridAbstract readReview
In one paragraph

Review in Current nutrition reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 7 pooled it
30.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

234 citing papers in PubMed, 7 syntheses or guidelines pooled it, 383 citations in OpenAlex.

  1. Pooled it
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  13. MIND diet-related plasma proteins are associated with Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Ferroptotic neurodegeneration and diet: a narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  20. Advancing mental health for all: WPA 2023-2026 action plan on clinical education and healthy lifestyles.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
    Article

174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrea M McGrattanInstitute of Health and Society and Newcastle University Institute of Ageing, Newcastle University, Biomedical Research Building, Campus of Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
Bernadette McGuinnessCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
Michelle C McKinleyCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
Frank KeeCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
Peter PassmoreCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
Jayne V WoodsideCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
Claire T McEvoyCentre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK. c.mcevoy@qub.ac.uk.
Queen's University Belfast · GBNewcastle University · GB

Funding

The Dunhill Medical Trust R514/1116Wellcome Trust 202097/Z/16/Z
6 · The paper itself

Abstract

purpose of reviewNutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function. RECENT

findingsAnti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation. Diet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.

Indexed as

DietInflammationAlzheimer DiseaseAntioxidantsBrainCognitionCognition DisordersCognitive AgingCognitive DysfunctionDietary Approaches To Stop HypertensionDiet, MediterraneanDiet TherapyElder Nutritional Physiological PhenomenaFatty Acids, Omega-3Gastrointestinal MicrobiomeHumansAntioxidantsFatty Acids, Omega-3PolyphenolsAlzheimer’s diseaseCognitionCognitive ageingCognitive functionDietDietary approaches to stop hypertension (DASH)Dietary patternsInflammationMechanismsMediterranean diet (MD)NutrientsPathwaysPro-inflammatory diets

Identifiers

PMID30949921
PMCPMC6486891
OpenAlexW2934530273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.