ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.Health technology assessment (Winchester, England) · 2024Pooled it
- Thromboprophylaxis during pregnancy and the puerperium: a systematic review and economic evaluation to estimate the value of future research.Health technology assessment (Winchester, England) · 2024Pooled it
- Patient-Reported Outcomes in Venous Thromboembolism: A Systematic Review of the Literature, Current Challenges, and Ways Forward.Journal of the American Heart Association · 2023Pooled it
- Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism.Nature reviews. Cardiology · 2026Review
- Risk of venous thrombosis and pulmonary embolism in older in-patients with mental illness: systematic review.BJPsych bulletin · 2026Review
- Fatigue after pulmonary embolism-prevalence and predictors.Frontiers in cardiovascular medicine · 2026Article
- Key elements of follow-up care after acute pulmonary embolism focusing on long-term sequelae: a Delphi study among European experts.European heart journal. Quality of care & clinical outcomes · 2025Article
- A Retrospective Perspective: Evaluating Pulmonary Embolism Risk Factors and Survival Trends.Annals of African medicine · 2025Article
- Hemostatic and Inflammatory Biomarkers are Associated with Functional Limitations after Venous Thromboembolism: A Prospective Cohort Study.Seminars in thrombosis and hemostasis · 2025Article
- Assessing Health-Related Quality of Life of Patients with Pulmonary Embolism with the Heart QoL Questionnaire.Medicina (Kaunas, Lithuania) · 2025Article
- Diagnostic Performance of Quantitative Computed Tomography Pulmonary Angiography Parameters in Patients With Pulmonary Embolism.Pulmonary medicine · 2025Article
- Psychological Impact of Pulmonary Embolism: A Narrative Review.Journal of community hospital internal medicine perspectives · 2025Review
- The impact of pulmonary embolism on health outcomes of COVID-19 at 3 months after hospitalization.Research and practice in thrombosis and haemostasis · 2024Article
- Quality of life in oncological patients with venous thromboembolic disease.Research and practice in thrombosis and haemostasis · 2024Review
- Association between severity of pulmonary embolism and health-related quality of life.Journal of thrombosis and haemostasis : JTH · 2024Article
- Effectiveness and cost effectiveness of pharmacological thromboprophylaxis for medical inpatients: decision analysis modelling study.BMJ medicine · 2024Article
- Time to diagnostic certainty for saddle pulmonary embolism in hospitalized patients.Biomolecules & biomedicine · 2023Observational
- Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review.Advances in respiratory medicine · 2023Review
- Two point-of-care test-based approaches for the exclusion of deep vein thrombosis in general practice: a cost-effectiveness analysis.BMC primary care · 2023Article
Corrections and comments
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Authors and funding
12 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLittle is known about the quality of life following pulmonary embolism (PE). The aim of the study was to assess the 12-month illness burden in terms of health-related quality of life (HrQoL) and mortality, in relation to differences in patient characteristics.
methodsThe PREFER in VTE registry, a prospective, observational study conducted in seven European countries, was used. Within 2 weeks following an acute symptomatic PE, patients were recruited and followed up for 12 months. Associations between patient characteristics and HrQoL (EQ-5D-5L) and mortality were examined using a regression approach.
resultsAmong 1399 PE patients, the EQ-5D-5L index score at baseline was 0.712 (SD 0.265), which among survivors gradually improved to 0.835 (0.212) at 12 months. For those patients with and without active cancer, the average index score at baseline was 0.658 (0.275) and 0.717 (0.264), respectively. Age and previous stroke were significant factors for predicting index scores in those with/without active cancer. Bleeding events but not recurrences had a noticeable impact on the HrQoL of patients without active cancer. The 12-month mortality rate post-acute period was 8.1%, ranging from 1.4% in Germany, Switzerland, and Austria to 16.8% in Italy. Mortality differed between patients with active cancer and those without (42.7% vs. 4.7%).
conclusionPE is associated with a substantial decrease in HrQoL at baseline which normalizes following treatment. PE is associated with a high mortality rate especially in patients with cancer, with significant country variation. Bleeding events, in particular, impact the burden of PE.
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