ArticleJournal of neurology2019
Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development and validation of a risk prediction model for mild cognitive impairment in older Chinese adults with chronic diseases.BMC geriatrics · 2026Observational
- The experience of long-term care staff caring for people with dementia in low- and middle-income Countries (LMICs): A qualitative evidence synthesis.Dementia (London, England) · 2026Article
- Multi-modal machine learning approach for early detection of neurodegenerative diseases leveraging brain MRI and wearable sensor data.PLOS digital health · 2025Article
- Differences in Finger Dexterity in Patients With Mild and Moderate Alzheimer's Disease-A Study of Cognitive Function by Disease Severity.Brain and behavior · 2025Article
- Examining the Cognitive Underpinnings of Functional Decline in Prodromal Alzheimer's Disease: Insights From the Details of Functions of Everyday Life (DoFEL) Scale.Journal of aging research · 2025Article
- Diagnostic utility and psychometric properties of the Technology Activities of Daily Living Questionnaire (T-ADLQ) in people with non-formally educated with Alzheimer's disease in Lima, Peru.Frontiers in aging neuroscience · 2025Article
- A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What', 'How', 'To Whom', and 'How Much' Questions.Journal of Alzheimer's disease : JAD · 2024Review
- Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer's disease.Frontiers in neurology · 2024Article
- Vestibular dysfunction and its association with cognitive impairment and dementia.Frontiers in neuroscience · 2024Review
- The "when" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.Neuropsychology · 2023Article
- Neurological soft signs and brain morphology in people living with HIV.Journal of neurovirology · 2022Article
- Predictors of functional impairment and awareness in people with dementia, mild cognitive impairment and healthy older adults from a middle-income country.Frontiers in psychiatry · 2022Article
- Apathy, Executive Function, and Emotion Recognition Are the Main Drivers of Functional Impairment in Behavioral Variant of Frontotemporal Dementia.Frontiers in neurology · 2021Article
- Spatial navigation and dual-task performance in patients with Dementia that present partial dependence in instrumental activity of daily living.IBRO reports · 2020Article
- Course of activities of daily living in nursing home residents with dementia from admission to 36-month follow-up.BMC geriatrics · 2020Article
- Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis.Frontiers in aging neuroscience · 2020Article
- Mild cognitive impairment history and current procedures in low- and middle-income countries: a brief review.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundImpairments in activities of daily living (ADL) are a criterion for Alzheimer's disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD.
methodsADL were evaluated with the Technology-Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via voxel-based morphometry.
resultsOur results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus.
conclusionsThe association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.
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