ArticleNeuroradiology2019
Structural and functional abnormalities of vision-related brain regions in cirrhotic patients: a MRI study.
Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Brain Gray Matter Alterations in Hepatic Encephalopathy: A Voxel-Based Meta-Analysis of Whole-Brain Studies.Frontiers in human neuroscience · 2022Pooled it
- Gray matter alterations and neurotransmitter system associations in hepatitis B virus-related cirrhosis: insights into neuropathogenesis and therapeutic targets.Neuroradiology · 2025Article
- Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy.Magnetic resonance letters · 2025Article
- Spontaneous neural activity changes in minimal hepatic encephalopathy before and 1 month after liver transplantation.Frontiers in human neuroscience · 2025Article
- Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas.Tomography (Ann Arbor, Mich.) · 2024Article
- MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders.Frontiers in aging neuroscience · 2024Article
- Dynamic evolution of brain structural patterns in liver transplantation recipients: a longitudinal study based on 3D convolutional neuronal network model.European radiology · 2023Article
- Changes in dynamic and static brain fluctuation distinguish minimal hepatic encephalopathy and cirrhosis patients and predict the severity of liver damage.Frontiers in neuroscience · 2023Article
- Identification of minimal hepatic encephalopathy based on dynamic functional connectivity.Brain imaging and behavior · 2021Article
- Abnormal Gray Matter Volume and Functional Connectivity in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Parkinson's disease · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposePrevious studies have focused on global cerebral alterations observed in cirrhosis. However, little was known about the specific abnormalities of vision-related brain regions in cirrhotic patients. In this study, we sought to explore neurological alterations of vision-related regions by measuring brain resting-state network connectivity, based on the structural investigation in cirrhotic patients without clinical sign of hepatic encephalopathy (HE).
methodsStructural and functional magnetic resonance image (MRI) data were collected from 20 hepatitis B virus (HBV)-related cirrhotic patients without clinical sign of HE and from 20 healthy controls (HC). Voxel-based morphometric (VBM) analysis and brain functional network analysis were performed to detect abnormalities in cerebral structure and function.
resultsCirrhotic patients showed regions with the most significant gray matter reduction primarily in vision-related brain regions, including the bilateral lingual gyri, left putamen, right fusiform gyrus, and right calcarine gyrus, and other significant gray matter reductions were distributed in bilateral hippocampus. Based on structural investigation focused on vision-related regions, brain functional network analysis revealed decreased functional connectivity between brain functional networks within vision-related regions (primary visual network (PVN), higher visual network (HVN), visuospatial network (VSN)) in the patient group compared with HC group.
conclusionThese results indicate that structural and functional impairment were evident in the vision-related brain regions in cirrhotic patients without clinical sign of hepatic encephalopathy. The physiopathology and clinical relevance of these changes could not be ascertained from the present study, which provided a basis for further evolution of the disease.
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