ArticleOpen forum infectious diseases2019
History of Depression and Increased Risk of Sternal Wound Infection After Cardiothoracic Surgery: A Novel and Potentially Modifiable Risk Factor.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- An interpretable deep learning framework for predictive modeling of postoperative infections in ICU patients.PloS one · 2026Article
- Mediterranean Diet Adherence, Sleep Disturbances and Emotional Well-Being in Skin Ulcer Burden: Insights from a Monocentric Registry.Nutrients · 2025Article
- Intrathecal drug delivery systems: A case series advancing surgical, clinical, and technological safety with broader implications for invasive neuromodulation therapies.SAGE open medical case reports · 2025Article
- The effects of preoperative alcohol, tobacco, and psychological stress on postoperative complications: a prospective observational study.BMC anesthesiology · 2021Observational
- The Monitoring of Psychosocial Factors During Hospitalization Before and After Cardiac Surgery Until Discharge From Cardiac Rehabilitation: A Research Protocol.Frontiers in psychology · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundSternal wound infection (SWI) is a leading cause of postoperative disease and death; the risk factors for SWI remain incompletely understood. The goal of the current study was to investigate the relationship between a preoperative history of depression and the risk of SWI after cardiothoracic surgery.
methodsAmong patients undergoing cardiothoracic surgery in a major academic medical center between 2007 and 2012, those in whom SWI developed (n = 129) were matched, by date of surgery, with those in whom it did not (n = 258). Multivariable logistic regression was used to examine the strength of relationships between risk factors and development of infection. History of depression was defined as a composite variable to increase the sensitivity of detection.
resultsHistory of depression as defined by our composite variable was associated with increased risk of SWI (adjusted odds ratio, 2.4; 95% confidence interval, 1.2-4.7;
conclusionsHistory of depression was associated with increased risk of SWI. Future prospective studies are warranted to further investigate this relationship. Depression is highly treatable, and increased efforts to identify and treat depression preoperatively may be a critical step toward preventing infection-related disease and death.
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