Evidence map›Paper›PMID 30949523›Full record

ArticleOpen forum infectious diseases2019

Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study.

William J Liu, Foday R Sesay, Antoine Coursier, Barbara Knust, Jaclyn E Marrinan, Shannon Whitmer, Suzanna L R McDonald, Philippe Gaillard, Yang Liu, Qiudong Su and 14 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Ebola virus disease.Nature reviews. Disease primers · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 4 countries.

William J LiuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Foday R SesayThe Sierra Leone Ministry of Defense, Freetown, Sierra Leone.
Antoine CoursierWorld Health Organization, Geneva, Switzerland.
Barbara KnustViral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jaclyn E MarrinanWorld Health Organization, Geneva, Switzerland.
Shannon WhitmerViral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Suzanna L R McDonaldWorld Health Organization, Geneva, Switzerland.
Philippe GaillardWorld Health Organization, Geneva, Switzerland.
Yang LiuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Qiudong SuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yong ZhangNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Ian CrozierWorld Health Organization, Geneva, Switzerland.
Archchun AriyarajahWorld Health Organization, Geneva, Switzerland.
Marylin CarinoWorld Health Organization, Geneva, Switzerland.
Thomas MassaquoiThe Sierra Leone Ministry of Defense, Freetown, Sierra Leone.
Nathalie BroutetWorld Health Organization, Geneva, Switzerland.
Wenbo XuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Guizhen WuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Ute StröherViral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
George F GaoNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Pierre FormentyWorld Health Organization, Geneva, Switzerland.
Foday SahrThe Sierra Leone Ministry of Defense, Freetown, Sierra Leone.
Gibrilla F DeenThe Sierra Leone Ministry of Health and Sanitation, Freetown, Sierra Leone.
Sierra Leone Ebola Virus Persistence Study Group
World Health Organization · CHMinistry of Defence · SLNational Institute for Viral Disease Control and Prevention · CNCenters for Disease Control and Prevention · USUniversity of Sierra Leone · SL

Funding

World Health Organization 001
6 · The paper itself

Abstract

The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.

Indexed as

clinical sequelaeEbola virusimmune responsesvirus genomevirus persistence

Identifiers

PMID30949523
PMCPMC6440679
OpenAlexW2916611379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.