ArticleGastroenterology and hepatology from bed to bench2019
Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology.
Article in Gastroenterology and hepatology from bed to bench, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Peptidomic changes in human serous colorectal cancer patients.Journal of gastrointestinal oncology · 2023Article
- Expression and Clinical Significance of Novel Long Noncoding RNA Fibroblast Growth Factor 10AS and FGF10 in Colorectal Cancer.Cell journal · 2021Article
- Identification of the effects of acid-resistantIranian journal of basic medical sciences · 2021Article
- Identification of Monotonically Differentially Expressed Genes across Pathologic Stages for Cancers.Journal of oncology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimGene expression profile analysis of colon cancer grade II into grade III transition by using system biology.
backgroundColon cancer is one of lethal cancer in men and women. Treatment in advanced colon cancer is difficult and survival rate is low.
methodsGene expression profiles of children patients with non-preforated appendicitis in comparison with the samples with non- appendicitis abdominal pain are analysis via protein - protein interaction PPI and the critical compounds are introduced by STITCH.
resultsSix critical genes including MAPK3, AKT1, SRC, TP53, GAPDH, and ALB were identified as a possible biomarker panel related to colon cancer grade II to III transition. Among these critical genes roles of MAPK3, AKT1, SRC, TP53 are highlighted.
conclusionIt was concluded that target therapy to regulate SRC and TP53 may be the effective therapeutic way to treatment of colon cancer and more researches in necessary to design drugs for these purposes.
Indexed as
Identifiers
30949321PMC6441480What OpenQuestion holds
Registered trials
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