Evidence map›Paper›PMID 30949172›Full record

ArticleFrontiers in immunology2019

Transient Expression of GATA3 in Hematopoietic Stem Cells Facilitates Helper Innate Lymphoid Cell Differentiation.

Dejene M Tufa, Ashley M Yingst, Tyler Shank, Seonhui Shim, George Devon Trahan, Jessica Lake, Renee Woods, Kenneth L Jones, Michael R Verneris

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Early Development of Innate Lymphoid Cells.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  6. Article
  7. Article
  8. [Current status of research on group 2 innate lymphocytes in allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dejene M TufaDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Ashley M YingstDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Tyler ShankDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Seonhui ShimDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
George Devon TrahanDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Jessica LakeDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Renee WoodsDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Kenneth L JonesDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
Michael R VernerisDepartment of Pediatric Hematology, Oncology and BMT, School of Medicine, University of Colorado, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USCenter for Cancer and Blood Disorders · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune RecoveryR01AI100879 · NIAID · UNIVERSITY OF MINNESOTA · PI VERNERIS, MICHAEL R. · 2013 to 2017
$1.9M
NCI NIH HHS P30 CA046934NIAID NIH HHS R01 AI100879
6 · The paper itself

Abstract

Helper Innate lymphoid cells (ILCs) are tissue resident lymphocytes that play a critical role in a number of biological processes. Several transcription factors are required for the differentiation of hematopoietic stem cells (HSCs) into ILCs. Recent studies demonstrate GATA3 as a transcriptional regulator that plays an essential role in ILC development. We aimed to modulate the differentiation of human cord blood-derived CD34

Indexed as

Immunity, InnateCell DifferentiationGATA3 Transcription FactorGene Expression RegulationHematopoietic Stem CellsHumansT-Lymphocytes, Helper-InducerGATA3 protein, humanGATA3 Transcription FactordifferentiationelectroporationGATA3helper ILCsHSCs

Identifiers

PMID30949172
PMCPMC6438154
OpenAlexW2924690352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.