Evidence map›Paper›PMID 30949170›Full record

ArticleFrontiers in immunology2019

TLR3 Activation of Intratumoral CD103

Emiliano Roselli, Paula Araya, Nicolás Gonzalo Núñez, Gerardo Gatti, Francesca Graziano, Christine Sedlik, Philippe Benaroch, Eliane Piaggio, Mariana Maccioni

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 34 citations in OpenAlex.

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  16. Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  19. Identification of a Novel Risk Model: A Five-Gene Prognostic Signature for Pancreatic Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Emiliano RoselliDepartment of Clinical Biochemistry, Faculty of Chemical Sciences, Center for Research in Clinical Biochemistry and Immunology, National University of Cordoba, Cordoba, Argentina.
Paula ArayaDepartment of Clinical Biochemistry, Faculty of Chemical Sciences, Center for Research in Clinical Biochemistry and Immunology, National University of Cordoba, Cordoba, Argentina.
Nicolás Gonzalo NúñezInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Gerardo GattiFundación para el Progreso de la Medicina, Laboratorio de Investigación en Cáncer, Cordoba, Argentina.
Francesca GrazianoINSERM U932, Institut Curie, Paris, France.
Christine SedlikINSERM U932, Institut Curie, Paris, France.
Philippe BenarochINSERM U932, Institut Curie, Paris, France.
Eliane PiaggioINSERM U932, Institut Curie, Paris, France.
Mariana MaccioniDepartment of Clinical Biochemistry, Faculty of Chemical Sciences, Center for Research in Clinical Biochemistry and Immunology, National University of Cordoba, Cordoba, Argentina.
Universidad Nacional de Córdoba · ARInserm · FRInstitut Curie · FRFundación para la Investigación, Docencia y Prevención del Cáncer · ARUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combined therapies with CI. Recently, we reported that intratumoral administration of naked poly A:U, a dsRNA mimetic empirically used in early clinical trials with some success, delays tumor growth and prolongs mice survival in several murine cancer models. Here, we show that CD103

Indexed as

AnimalsAntigens, CDB-LymphocytesCD8-Positive T-LymphocytesDendritic CellsIntegrin alpha ChainsLymphocytes, Tumor-InfiltratingMiceMice, TransgenicNeoplasms, ExperimentalPoly A-UT-Lymphocytes, RegulatoryToll-Like Receptor 3Tumor Microenvironmentalpha E integrinsAntigens, CDIntegrin alpha ChainsPoly A-UTLR3 protein, mouseToll-Like Receptor 3cancer immunotherapyCD103+ cDC1dsRNA mimeticsTLR3tumor-infiltrate

Identifiers

PMID30949170
PMCPMC6435583
OpenAlexW2922876350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.