Evidence map›Paper›PMID 30949032›Full record

ReviewFrontiers in cellular neuroscience2019

Mast Cell Neural Interactions in Health and Disease.

Aditya Mittal, Varun Sagi, Mihir Gupta, Kalpna Gupta

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Non-neuronal targets for migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
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  14. p16Immunity & ageing : I & A · 2024
    Article
  15. Article
  16. Impact of TNF and IL-33 Cytokines on Mast Cells in Neuroinflammation.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Review
  19. Molecular Mechanisms of Neurogenic Inflammation of the Skin.International journal of molecular sciences · 2023
    Review
  20. UltramicronizedBiomolecules · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Aditya MittalVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Varun SagiVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Mihir GuptaDepartment of Neurosurgery, University of California, San Diego, San Diego, CA, United States.
Kalpna GuptaVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · USUniversity of California, San Diego · US

Funding

Cannabinoid-based therapy and approaches to quantify pain in sickle cell diseaseU01HL117664 · NHLBI · UNIVERSITY OF MINNESOTA · PI GUPTA, KALPNA · 2013 to 2018
$9.6M
NHLBI NIH HHS U01 HL117664
6 · The paper itself

Abstract

Mast cells (MCs) are located in the periphery as well as the central nervous system (CNS). Known for sterile inflammation, MCs play a critical role in neuroinflammation, which is facilitated by their close proximity to nerve fibers in the periphery and meninges of the spinal cord and the brain. Multifaceted activation of MCs releasing neuropeptides, cytokines and other mediators has direct effects on the neural system as well as neurovascular interactions. Emerging studies have identified the release of extracellular traps, a phenomenon traditionally meant to ensnare invading pathogens, as a cause of MC-induced neural injury. In this review article, we will discuss mechanisms of MC interaction with the nervous system through degranulation,

Indexed as

blood brain barrierendothelial cellinflammationmast cellnervous systempain

Identifiers

PMID30949032
PMCPMC6435484
OpenAlexW2923518955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.