Evidence map›Paper›PMID 30948793›Full record

ArticleCellular & molecular immunology2019

IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren's syndrome.

Xiang Lin, Xiaohui Wang, Fan Xiao, Kongyang Ma, Lixiong Liu, Xiaoqi Wang, Dong Xu, Fei Wang, Xiaofei Shi, Dongzhou Liu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 119 citations in OpenAlex.

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  9. The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Xiang Lin *Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-9065-2744
Xiaohui Wang *Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.
Fan XiaoDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.
Kongyang MaDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.
Lixiong LiuDepartment of Rheumatology and Immunology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Xiaoqi WangDepartment of Rheumatology and Immunology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Dong XuDepartment of Rheumatology, Peking Union Medical College Hospital, Beijing, China.
Fei WangDepartment of Rheumatology, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China.
Xiaofei ShiDepartment of Rheumatology, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China.
Dongzhou LiuDepartment of Rheumatology and Immunology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China. liu_dz2001@sina.com.
Yan ZhaoDepartment of Rheumatology, Peking Union Medical College Hospital, Beijing, China. zhaoyan_pumch2002@aliyun.com.
Liwei LuDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. liweilu@hku.hk.
City University of Hong Kong, Shenzhen Research Institute · CNJinan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Henan University of Science and Technology · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81771761, 91842304
6 · The paper itself

Abstract

Increased numbers of T follicular helper (Tfh) cells have been implicated in the development of autoimmune diseases including primary Sjögren's syndrome (pSS), but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear. Here, we first found negative correlations between IL-10

Indexed as

AdultAnimalsB-Lymphocytes, RegulatoryCells, CulturedDisease Models, AnimalFemaleGerminal CenterHumansImmune ToleranceInterleukin-10MaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedSjogren's SyndromeInterleukin-10Breg cellsPrimary Sjögren’s syndromeT follicular helper cells

Identifiers

PMID30948793
PMCPMC6884445
OpenAlexW2932978272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.