Evidence map›Paper›PMID 30948634›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Post-stress bacterial cell death mediated by reactive oxygen species.

Yuzhi Hong, Jie Zeng, Xiuhong Wang, Karl Drlica, Xilin Zhao

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 489 citations in OpenAlex.

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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yuzhi HongPublic Health Research Institute Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103.ORCID 0000-0003-4277-1834
Jie ZengState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province 361102, China.
Xiuhong WangPublic Health Research Institute Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103.
Karl DrlicaPublic Health Research Institute Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103.
Xilin ZhaoPublic Health Research Institute Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103; zhaox5@njms.rutgers.edu.ORCID 0000-0001-8375-8658
Rutgers, The State University of New Jersey · USXiamen University · CN

Funding

Novel fluoroquinolones for killing dormant Mycobacterium tuberculosisR01AI073491 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DRLICA, KARL A, KERNS, ROBERT JOHN · 2007 to 2015
$5.1M
Anaerobic shock as a novel treatment for tuberculosisDP2OD007423 · OD · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZHAO, XILIN · 2010 to 2010
$2.3M
NIAID NIH HHS R01 AI073491NIH HHS DP2 OD007423
6 · The paper itself

Abstract

Antimicrobial efficacy, which is central to many aspects of medicine, is being rapidly eroded by bacterial resistance. Since new resistance can be induced by antimicrobial action, highly lethal agents that rapidly reduce bacterial burden during infection should help restrict the emergence of resistance. To improve lethal activity, recent work has focused on toxic reactive oxygen species (ROS) as part of the bactericidal activity of diverse antimicrobials. We report that when

Indexed as

Cell DeathStress, PhysiologicalAmpicillinDnaB HelicasesEscherichia coliReactive Oxygen SpeciesAmpicillinDnaB HelicasesdnaB protein, E coliReactive Oxygen Speciesantimicrobialantioxidantdamage repairpoststress cellular responsereactive oxygen species

Identifiers

PMID30948634
PMCPMC6525477
OpenAlexW2927944686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.