Evidence map›Paper›PMID 30948514›Full record

ArticleThe Journal of biological chemistry2019

Human red and green cone opsins are

David Salom, Hui Jin, Thomas A Gerken, Clinton Yu, Lan Huang, Krzysztof Palczewski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Glycosylation of the retina.Biochemical Society transactions · 2026
    Review
  2. Article
  3. A short story on how chromophore is hydrolyzed from rhodopsin for recycling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Review
  4. Proteomic analysis of diabetic retinas.Frontiers in endocrinology · 2023
    Article
  5. AInternational journal of molecular sciences · 2022
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David SalomGavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, Irvine, California 92697; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106. Electronic address: dsalom1@uci.edu.
Hui JinDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106.
Thomas A GerkenDepartment of Biochemistry and Chemistry, Case Western Reserve University, Cleveland, Ohio 44106.
Clinton YuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697.
Lan HuangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697.
Krzysztof PalczewskiGavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, Irvine, California 92697; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106. Electronic address: kpalczew@uci.edu.
University of California, Irvine · USCase Western Reserve University · US

Funding

Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
Proteomics of the Proteasome Interacting NetworksR01GM074830 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2005 to 2022
$6.1M
Initiation and Regulation of Mucin-Type O-GlycosylationR01GM113534 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI GERKEN, THOMAS A · 2018 to 2023
$1.6M
Structural dynamics and function of the COP9 signalosomeR01GM130144 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2018 to 2021
$1.2M
NEI NIH HHS R24 EY027283NIGMS NIH HHS R01 GM074830NIGMS NIH HHS R01 GM113534NIGMS NIH HHS R01 GM130144
6 · The paper itself

Abstract

There are fundamental differences in the structures of outer segments between rod and cone photoreceptor cells in the vertebrate retina. Visual pigments are the only essential membrane proteins that differ between rod and cone outer segments, making it likely that they contribute to these structural differences. Human rhodopsin is

Indexed as

Cone OpsinsProtein Processing, Post-TranslationalAnimalsCattleChickensGlycosylationHEK293 CellsHumansMacaca fascicularisProtein DomainsRetinal Cone Photoreceptor CellsSpecies SpecificityXenopus laevisCone OpsinsG protein-coupled receptor (GPCR)receptorreceptor structure-functionretinal metabolismrhodopsin

Identifiers

PMID30948514
PMCPMC6527158
OpenAlexW2934581115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.