Evidence map›Paper›PMID 30948508›Full record

ArticleThe Journal of biological chemistry2019

Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.

William N Addison, Martin Pellicelli, René St-Arnaud

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

William N AddisonShriners Hospitals for Children-Canada, Montreal, Quebec, Canada.
Martin PellicelliShriners Hospitals for Children-Canada, Montreal, Quebec, Canada.
René St-ArnaudShriners Hospitals for Children-Canada, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Surgery, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Electronic address: rst-arnaud@shriners.mcgill.ca.
Shriners Hospitals for Children - Canada · CAMcGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional cofactor nascent polypeptide-associated complex and co-regulator α (NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by binding to Jun proto-oncogene, AP-1 transcription factor subunit (cJUN) and potentiating the transactivation of AP-1 targets such as osteocalcin (

Indexed as

Cell DifferentiationTranscription, GeneticActive Transport, Cell NucleusAnimalsCell NucleusHEK293 CellsHumansMatrix Metalloproteinase 9MiceMolecular ChaperonesNuclear ProteinsOsteoblastsPhosphorylationProtein Phosphatase 1Proto-Oncogene MasProto-Oncogene Proteins c-junJUN protein, humanMAS1 protein, humanMatrix Metalloproteinase 9MMP9 protein, humanMolecular Chaperonesnascent-polypeptide-associated complexNuclear ProteinsPPP1CA protein, humanProtein Phosphatase 1Proto-Oncogene MasProto-Oncogene Proteins c-juntranscription factor BTF3Transcription FactorsAP1 transcription factor (AP-1)cell differentiationcell signalingc-Jun transcription factorJUN, transcriptionnascent polypeptide-associated complex and co-regulator alpha (NACA)osteoblastphosphatasePP1AProtein phosphatase 1 catalytic subunit alpha (PP1A)αNAC

Identifiers

PMID30948508
PMCPMC6527172
OpenAlexW2931657607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.