ArticleLife science alliance2019
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control
Open access · goldAbstract read
In one paragraph
Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Stem cell-based tactics in the remodeling and treatment of intestinal diseases.Stem cell research & therapy · 2026Review
- Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation.Experimental & molecular medicine · 2026Article
- CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy.RNA nanomed · 2025Article
- Human α-Defensin 5International journal of molecular sciences · 2023Article
- Multifaceted involvements of Paneth cells in various diseases within intestine and systemically.Frontiers in immunology · 2023Review
- Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease.BMB reports · 2023Review
- Article
- Current and future aspects of IBD research and treatment: The 2022 perspective.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
- Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Review
- Review
- Gut Microbiota and Intestinal Trans-Epithelial Permeability.International journal of molecular sciences · 2020Review
- Plasticity of Paneth cells and their ability to regulate intestinal stem cells.Stem cell research & therapy · 2020Review
- Organoids in immunological research.Nature reviews. Immunology · 2020Review
- Article
- Use of organoids to study regenerative responses to intestinal damage.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.Cancers · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 3 countries.
Ruixue LiuKey Laboratory of Human Disease Comparative Medicine, the Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy Institute of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Richard MorigglLudwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Dongsheng ZhangDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Haifeng LiKey Laboratory of Human Disease Comparative Medicine, the Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy Institute of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Rebekah KarnsDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MI, USA.
Haitao NiuKey Laboratory of Human Disease Comparative Medicine, the Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy Institute of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Christopher MayhewDivision of Developmental Biology, CCHMC, Cincinnati, OH, USA.
Carey WatsonDivision of Pediatric Surgery, CCHMC, Cincinnati, OH, USA.
Hansraj BangarDivision of Infectious Diseases, CCHMC, Cincinnati, OH, USA.
Sang-Wook ChaDivision of Developmental Biology, CCHMC, Cincinnati, OH, USA.
David HaslamDivision of Infectious Diseases, CCHMC, Cincinnati, OH, USA.
Tongli ZhangDepartment of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, OH, USA.
Shila GilbertDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Na LiKey Laboratory of Human Disease Comparative Medicine, the Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy Institute of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Michael HelmrathDivision of Pediatric Surgery, CCHMC, Cincinnati, OH, USA.
James WellsDivision of Developmental Biology, CCHMC, Cincinnati, OH, USA.
Lee DensonDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Xiaonan HanDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA xiaonan.han@cchmc.org.ORCID 0000-0001-5368-6489
Cincinnati Children's Hospital Medical Center · USChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Cincinnati Medical Center · USUniversity of Minnesota Medical Center · USUniversity of Veterinary Medicine Vienna · AT
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MCauses and consequences of neutrophil dysfunction in early onset Crohn's diseaseR01DK098231 · NIDDK · EMORY UNIVERSITY · PI DENSON, LEE ARMISTEAD, KUGATHASAN, SUBRA · 2013 to 2017
$3.3MREGULATION OF NICHE CELL DIFFERENTIATION TO SUSTAIN INTESTINAL STEM CELL REGENERATION AGAINST GUT INFLAMMATIONR01DK123299 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HAN, XIAONAN · 2020 to 2023
$1.4MRegulation of adult stem cell homeostatic response to inflammatory injuryR21AI103388 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HAN, XIAONAN · 2013 to 2014
$423kCauses and consequences of neutrophil dysfunction in early onset Crohn's diseaseR56DK098231 · NIDDK · EMORY UNIVERSITY · PI DENSON, LEE ARMISTEAD, KUGATHASAN, SUBRA · 2019 to 2019
$171kNIAID NIH HHS R21 AI103388NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK098231NIDDK NIH HHS R01 DK123299NIDDK NIH HHS R56 DK098231
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clostridioides difficileAnimalsbeta CateninCell DifferentiationCells, CulturedColitisDisease Models, AnimalFemaleHumansInduced Pluripotent Stem CellsMaleMiceMice, Inbred C57BLMice, TransgenicOrganoidsPaneth Cellsbeta CateninSTAT5A protein, humanStat5a protein, mouseSTAT5 Transcription FactorTumor Suppressor Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.