Evidence map›Paper›PMID 30948493›Full record

ArticleHaematologica2019

Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma.

Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni, Roberto Ria, Micaela Ricca, Ilaria Saltarella, Valeria Naponelli, Federica Maria Angela Rizzi, Roberto Perris and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Laura MazzeraDepartment of Medicine and Surgery, University of Parma, Parma.
Manuela AbeltinoDepartment of Medicine and Surgery, University of Parma, Parma.
Guerino LombardiIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini," Brescia.
Anna Maria CantoniDepartment of Veterinary Science, University of Parma, Parma.
Roberto RiaDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School, Bari.
Micaela RiccaIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini," Brescia.
Ilaria SaltarellaDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School, Bari.
Valeria NaponelliDepartment of Medicine and Surgery, University of Parma, Parma.
Federica Maria Angela RizziDepartment of Medicine and Surgery, University of Parma, Parma.
Roberto PerrisCenter for Molecular and Translational Oncology, University of Parma, Parma.
Attilio CorradiDepartment of Veterinary Science, University of Parma, Parma.
Angelo VaccaDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School, Bari.
Antonio BonatiDepartment of Medicine and Surgery, University of Parma, Parma.
Paolo LunghiCenter for Molecular and Translational Oncology, University of Parma, Parma p.lunghi@libero.it.
University of Parma · ITUniversity of Bari Aldo Moro · ITIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering that Aurora kinase inhibitors are currently under clinical investigation in hematologic cancers, the identification of molecular events that limit the response to such agents is essential for enhancing clinical outcomes. Here, we discover a NF-κB-inducing kinase (NIK)-c-Abl-STAT3 signaling-centered feedback loop that restrains the efficacy of Aurora inhibitors in multiple myeloma. Mechanistically, we demonstrate that Aurora inhibition promotes NIK protein stabilization

Indexed as

AnimalsApoptosisAurora Kinase AAurora Kinase BCell ProliferationCyclopropanesGene Expression Regulation, NeoplasticHumansMiceMice, Inbred NODMice, SCIDMultiple MyelomaNF-kappa BNF-kappaB-Inducing KinasePiperazinesProtein Kinase InhibitorsAURKA protein, humanAURKB protein, humanAurora Kinase AAurora Kinase BCyclopropanesNF-kappa BNF-kappaB-Inducing KinasePHA 680632PiperazinesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-ablPyrazolesPyrimidinesPyrrolesSTAT3 protein, humanSTAT3 Transcription FactorTNF Receptor-Associated Factor 2tozasertib

Identifiers

PMID30948493
PMCPMC6959191
OpenAlexW2929112109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.