ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Reorganization of Recurrent Layer 5 Corticospinal Networks Following Adult Motor Training.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Neural Network Connection Characteristics Between Motor Cortex and Spinal Cord During Rat Bipedal Walking.CNS neuroscience & therapeutics · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.bioRxiv : the preprint server for biology · 2025Article
- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training.Cell reports · 2024Article
- Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.Nature neuroscience · 2023Article
- Cellular computation and cognition.Frontiers in computational neuroscience · 2023Article
- Article
- Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement.Neuron · 2022Article
- Disengagement of Motor Cortex during Long-Term Learning Tracks the Performance Level of Learned Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neural manifold under plasticity in a goal driven learning behaviour.PLoS computational biology · 2021Article
- Encouraging an excitable brain state: mechanisms of brain repair in stroke.Nature reviews. Neuroscience · 2021Review
- Corticospinal Pathways and Interactions Underpinning Dexterous Forelimb Movement of the Rodent.Neuroscience · 2020Review
- Stability of motor cortex network states during learning-associated neural reorganizations.Journal of neurophysiology · 2020Article
- Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Review
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5 authors.
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Abstract
Recurrent synaptic connections between neighboring neurons are a key feature of mammalian cortex, accounting for the vast majority of cortical inputs. Although computational models indicate that reorganization of recurrent connectivity is a primary driver of experience-dependent cortical tuning, the true biological features of recurrent network plasticity are not well identified. Indeed, whether rewiring of connections between cortical neurons occurs during behavioral training, as is widely predicted, remains unknown. Here, we probe M1 recurrent circuits following motor training in adult male rats and find robust synaptic reorganization among functionally related layer 5 neurons, resulting in a 2.5-fold increase in recurrent connection probability. This reorganization is specific to the neuronal subpopulation most relevant for executing the trained motor skill, and behavioral performance was impaired following targeted molecular inhibition of this subpopulation. In contrast, recurrent connectivity is unaffected among neighboring layer 5 neurons largely unrelated to the trained behavior. Training-related corticospinal cells also express increased excitability following training. These findings establish the presence of selective modifications in recurrent cortical networks in adulthood following training.
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