Evidence map›Paper›PMID 30948475›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations.

Lindsey J Caldwell, Nick O Davies, Leonardo Cavone, Karolina S Mysiak, Svetlana A Semenova, Pertti Panula, J Douglas Armstrong, Catherina G Becker, Thomas Becker

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lindsey J CaldwellCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Nick O DaviesCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom, nck.dvs1@gmail.com thomas.becker@ed.ac.uk.
Leonardo CavoneCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Karolina S MysiakCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Svetlana A SemenovaNeuroscience Center and Department of Anatomy, University of Helsinki, 00290 Helsinki, Finland, and.
Pertti PanulaNeuroscience Center and Department of Anatomy, University of Helsinki, 00290 Helsinki, Finland, and.
J Douglas ArmstrongSchool of Informatics, University of Edinburgh, Edinburgh EH8 9AB, United Kingdom.
Catherina G BeckerCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Thomas BeckerCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom, nck.dvs1@gmail.com thomas.becker@ed.ac.uk.
University of Edinburgh · GBUniversity of Helsinki · FI

Funding

Biotechnology and Biological Sciences Research Council BB/M003892/1Medical Research Council
6 · The paper itself

Abstract

Adult zebrafish, in contrast to mammals, regenerate neurons in their brain, but the extent and variability of this capacity is unclear. Here we ask whether the loss of various dopaminergic neuron populations is sufficient to trigger their functional regeneration. Both sexes of zebrafish were analyzed. Genetic lineage tracing shows that specific diencephalic ependymo-radial glial (ERG) progenitor cells give rise to new dopaminergic [tyrosine hydroxylase-positive (TH

Indexed as

AgingAnimalsAxonsCell LineageCell ProliferationDiencephalonDopaminergic NeuronsFemaleImmune System PhenomenaMaleMicrogliaNerve RegenerationNeural Stem CellsNeurogenesisSexual Behavior, AnimalZebrafishanxietyGFAPmatingOlig2shoalingtyrosine hydroxylase

Identifiers

PMID30948475
PMCPMC6561686
OpenAlexW2953227834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.