ArticleScience (New York, N.Y.)2019
Thirst regulates motivated behavior through modulation of brainwide neural population dynamics.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers.
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Who cites it
232 citing papers in PubMed, 409 citations in OpenAlex.
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- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain.The European journal of neuroscience · 2026Article
- Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
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- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.bioRxiv : the preprint server for biology · 2026Article
- Neuromodulators Generate Multiple Context-Relevant Behaviors in Recurrent Neural Networks.Neural computation · 2026Article
- Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus.iScience · 2026Article
172 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from ~24,000 neurons in 34 brain regions during thirst-motivated choice behavior in 21 mice as they consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. After satiation, focal optogenetic activation of hypothalamic thirst-sensing neurons returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions that determine how a brainwide dynamical system transforms sensory input into behavioral output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.