ArticleBiomedical engineering online2019
Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology.
Article in Biomedical engineering online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review.Physical and engineering sciences in medicine · 2024Pooled it
- A deep learning approach for keratoconus detection using spatio-temporal features from corneal imaging.Scientific reports · 2026Article
- Hydrogels as Promising Carriers for Ophthalmic Disease Treatment: A Comprehensive Review.Gels (Basel, Switzerland) · 2026Review
- Time-dependent changes in corneal biomechanics after small incision lenticule extraction: an in vivo study.BMC ophthalmology · 2025Article
- A Novel Approach to Fabricate Early Keratoconus Phantom Models.Translational vision science & technology · 2025Article
- The Application of Terahertz Technology in Corneas and Corneal Diseases: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks.Frontiers in bioengineering and biotechnology · 2024Review
- Effect of corneal cross-linking on biomechanical changes following transepithelial photorefractive keratectomy and femtosecond laser-assisted LASIK.Frontiers in bioengineering and biotechnology · 2024Article
- Advancements in Nanogels for Enhanced Ocular Drug Delivery: Cutting-Edge Strategies to Overcome Eye Barriers.Gels (Basel, Switzerland) · 2023Review
- Corneal elastic property investigated by terahertz technology.Scientific reports · 2022Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
- Photocurable antimicrobial silk-based hydrogels for corneal repair.Journal of biomedical materials research. Part A · 2022Article
- Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second.Biomedical optics express · 2022Article
- Micron-scale hysteresis measurement using dynamic optical coherence elastography.Biomedical optics express · 2022Article
- A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application.International journal of bioprinting · 2022Article
- Determine Corneal Biomechanical Parameters by Finite Element Simulation and Parametric Analysis Based on ORA Measurements.Frontiers in bioengineering and biotechnology · 2022Article
- Differences of Corneal Biomechanics Among Thin Normal Cornea, Forme-Fruste Keratoconus, and Cornea After SMILE.Frontiers in bioengineering and biotechnology · 2022Article
- On the Relationship between Corneal Biomechanics, Macrostructure, and Optical Properties.Journal of imaging · 2021Article
- A Potential Screening Index of Corneal Biomechanics in Healthy Subjects, Forme Fruste Keratoconus Patients and Clinical Keratoconus Patients.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCorneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis of corneal surgery. Clinical available devices such as Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (Corvis ST) can provide corneal biomechanics related parameters, while corneal elastic modulus cannot be extracted directly from them at present. The aim of this study is to suggest a method to determine corneal elastic modulus based on the results of Corvis ST test according to Reissner's theory on the relation between stress and small displacement in shallow spherical shell.
resultsFive rabbits (10 eyes) and 10 healthy humans (20 eyes) were measured with Corvis ST to obtain the normal range of corneal elastic modulus. Results showed Corneal elastic modulus of rabbit was 0.16 MPa to 0.35 MPa, human corneal elastic modulus was 0.16-0.30 MPa. Rabbit corneas were also measured at different intraocular pressures (IOP), and results showed corneal elastic modulus, first applanation time (A1T) and stiffness parameter (SP-A1) were positively correlated with IOP. Deformation amplitude (DA), the second applanations time (A2T), and peak distance (PD) were negatively correlated with IOP. Finite element method was used to simulate the Corvis measurements according to the calculated elastic modulus and the simulated corneal apical displacements were agreement with experimental results in general.
conclusionsThe method to determine corneal elastic modulus based on Corvis test according to the relationship between force and displacements of shallow spherical shell is convenient and effective.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.