SynthesisBMC cardiovascular disorders2019
Subclinical thyroid dysfunction is associated with adverse prognosis in heart failure patients with reduced ejection fraction.
Synthesis in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Pooled it
- Intersecting Endocrine Pathways in Cardiomyopathy: The Role of Metabolic Burden in Structural Heart Disease.Biomedicines · 2025Article
- Interpretable AI-driven multi-objective risk prediction in heart failure patients with thyroid dysfunction.Frontiers in digital health · 2025Article
- Impairment of Left Ventricular Function in Hyperthyroidism Caused by Graves' Disease: An Echocardiographic Study.Journal of clinical medicine · 2024Article
- Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.American journal of physiology. Heart and circulatory physiology · 2024Article
- Subclinical hypothyroidism and clinical outcomes after cardiac surgery: A systematic review and meta-analysis.JTCVS open · 2024Article
- Thyroid and cardiovascular diseases.Turkish journal of medical sciences · 2024Review
- [Type 2 amiodarone-induced thyrotoxicosis: prevalence, time and predictors of development].Problemy endokrinologii · 2023Article
- Prognostic role and relationship of thyroid dysfunction and lipid profile in hospitalized heart failure patients.Clinical cardiology · 2023Article
- Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study.Iranian journal of medical sciences · 2023Article
- Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention.Ghana medical journal · 2023Observational
- Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People.International journal of endocrinology · 2023Article
- Approach to adult patients with primary hypothyroidism in some special situations: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM).Archives of endocrinology and metabolism · 2022Article
- Cardiac manifestations in hyperthyroidism.Reviews in cardiovascular medicine · 2022Review
- Thyroid disorders and cardiovascular manifestations: an update.Endocrine · 2022Review
- Long-Term, Single-Centre Observation of Patients with Cardiac Implantable Electronic Devices.Medicina (Kaunas, Lithuania) · 2021Article
- Thyroid and heart, a clinically relevant relationship.Journal of endocrinological investigation · 2021Review
- A practical contemporary approach to decision-making on subclinical hypothyroidism.Archives of endocrinology and metabolism · 2021Review
- Subclinical Hypothyroidism in Geriatric Population and Its Association With Heart Failure.Cureus · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubclinical thyroid dysfunction whose typical patterns include subclinical hypothyroidism and subclinical hyperthyroidism, has been indicated to be associated with an increased risk of heart failure (HF). However, the relationship between subclinical thyroid dysfunction and the clinical outcomes of HF patients is uncertain. This meta-analysis was conducted to assess the association between subclinical thyroid dysfunction and the clinical outcomes of HF patients.
methodsPubmed, Embase, Web of Science and Cochrane Central Register of Clinical Trials were searched for eligible studies published up to August 1, 2018 which reported the association between subclinical thyroid dysfunction and the clinical outcomes of HF patients. The pooled hazard ratio (HR) with the corresponding 95% confidence interval (CI) was used to assess the association.
resultsFourteen studies met the eligibility criteria and a total of 21,221 patients with heart failure were included in the meta-analysis. Compared with HF patients with euthyroidism, the pooled HR of subclinical hypothyroidism for all-cause mortality was 1.45 (95% CI 1.26-1.67) in a randomized effects model with mild heterogeneity (I
conclusionsBoth subclinical hypothyroidism and subclinical hyperthyroidism are associated with adverse prognosis in patients with HF. Subclinical thyroid dysfunction may be a useful and promising predictor for the long-term prognosis in HF patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.