Evidence map›Paper›PMID 30947338›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2019

Vegetarian-Based Dietary Patterns and their Relation with Inflammatory and Immune Biomarkers: A Systematic Review and Meta-Analysis.

Joel C Craddock, Elizabeth P Neale, Gregory E Peoples, Yasmine C Probst

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 11 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 11 syntheses or guidelines pooled it, 174 citations in OpenAlex.

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  8. Vegetarian and Vegan Diet in Fibromyalgia: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
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  17. Assessing the effects of alternative plant-based meatsJournal of nutritional science · 2022
    Trial
  18. Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026
    Review
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joel C CraddockSchool of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Elizabeth P NealeSchool of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Gregory E PeoplesSchool of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Yasmine C ProbstSchool of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
University of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary patterns with substantial proportions of energy from plant sources have been associated with favorable biomarkers of low-grade inflammation. Less is known of the relation between vegetarian-based dietary patterns and markers of inflammation and immune status. This systematic review and meta-analysis aimed to determine the relation between vegetarian-based dietary patterns and inflammatory and immune markers (C-reactive protein, tumour necrosis factor α, fibrinogen, natural killer cells, leukocytes, lymphocytes, thrombocytes, interleukins, and immunoglobulins). PubMed, Medline, and Cochrane scientific databases were searched to identify relevant studies. Random effects meta-analyses were conducted to assess the weighted mean differences (WMDs) for each outcome variable between vegetarian and non-vegetarian groups. Thirty observational and 10 intervention studies were included in the review. Pooled effects of vegetarian-based dietary patterns were associated with significantly lower concentrations of CRP (WMD: -0.61 mg/L; 95% CI: -0.91, -0.32 mg/L; P = 0.0001), fibrinogen (WMD: -0.22 g/L; 95% CI: -0.41, -0.04 mg/L; P = 0.02), and total leukocyte (WMD: -0.62 × 10(3)/μL; 95% CI -1.13 × 10(3), -0.10 × 10(3)/μL; P = 0.02) compared with those following non-vegetarian dietary patterns in observational studies. Insufficient data were identified for a meta-analysis of intervention studies. This study provides evidence that vegetarian-based dietary patterns are associated with lowered serum C-reactive protein, fibrinogen, and total leukocyte concentrations. Future research should focus on large-scale intervention trials, contrasting differences in inflammation and immune status and function between vegetarian and non-vegetarian-based populations.

Indexed as

Diet, VegetarianBiomarkersBlood ProteinsC-Reactive ProteinHumansInflammationInflammation MediatorsBiomarkersBlood ProteinsC-Reactive ProteinInflammation MediatorsCRPdietdietary patternsIL-6immune functioninflammationmeta-analysissystematic reviewveganvegetarian

Identifiers

PMID30947338
PMCPMC6520040
OpenAlexW2927950499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.