ArticlePLoS neglected tropical diseases2019
Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Impact of Day/Night Cycle Temperature Regimes on Zika Virus Replication in Mosquito Cells and Implications for Transmission Potential.Pathogens (Basel, Switzerland) · 2026Article
- EliminatingInsects · 2026Article
- Tracking the early spatio-temporal dynamics of phytoplasma multiplication within its leafhopper vector.Microbiology (Reading, England) · 2026Article
- Overview of Chikungunya Virus Pathogenesis, Genome Variation, Epidemiology, and Control.Virus research · 2026Review
- A systematic review and meta-analysis of Zika virus epidemiology.Nature health · 2026Article
- Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors.Npj viruses · 2025Article
- Thermal adaptation inProceedings. Biological sciences · 2025Article
- Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB.Scientific reports · 2025Article
- Variations in the Bacterial Ecosystems of Mosquito Populations - Haikou and Sanya Cities, Hainan Province, China, 2019.China CDC weekly · 2025Article
- Identification of visible and near-infrared signature peaks for arboviruses and Plasmodium falciparum.PloS one · 2025Article
- Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector.Journal of medical virology · 2024Article
- Mosquito ageing modulates the development, virulence and transmission potential of pathogens.Proceedings. Biological sciences · 2024Article
- Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine.Nature communications · 2022Article
- First Report of the Detection of DENV1 in Human Blood Plasma with Near-Infrared Spectroscopy.Viruses · 2022Article
- Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background.PLoS neglected tropical diseases · 2022Article
- Reporter Flaviviruses as Tools to Demonstrate Homologous and Heterologous Superinfection Exclusion.Viruses · 2022Article
- The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential.PLoS neglected tropical diseases · 2022Article
- The Common Mosquito (Frontiers in veterinary science · 2022Article
- Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control.Journal of pest science · 2022Review
- Microbial Composition in Larval Water Enhances Aedes aegypti Development but Reduces Transmissibility of Zika Virus.mSphere · 2021Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent epidemics of Zika virus (ZIKV) in the Pacific and the Americas have highlighted its potential as an emerging pathogen of global importance. Both Aedes (Ae.) aegypti and Ae. albopictus are known to transmit ZIKV but variable vector competence has been observed between mosquito populations from different geographical regions and different virus strains. Since Australia remains at risk of ZIKV introduction, we evaluated the vector competence of local Ae. aegypti and Ae. albopictus for a Brazilian epidemic ZIKV strain. In addition, we evaluated the impact of daily temperature fluctuations around a mean of 28°C on ZIKV transmission and extrinsic incubation period. METHODOLOGY/PRINCIPAL
findingsMosquitoes were orally challenged with a Brazilian ZIKV strain (8.8 log CCID50/ml) and maintained at either 28°C constant or fluctuating temperature conditions. At 3, 7 and 14 days post-infection (dpi), ZIKV RNA copies were quantified in mosquito bodies, as well as wings and legs, using qRT-PCR, while virus antigen in saliva (a proxy for transmission) was detected using a cell culture ELISA. Despite high body and disseminated infection rates in both vectors, the transmission rates of ZIKV in saliva of Ae. aegypti (50-60%) were significantly higher than in Ae. albopictus (10%) at 14 dpi. Both species supported a high viral load in bodies, with no significant differences between constant and fluctuating temperature conditions. However, a significant difference in viral load in wings and legs between species was observed, with higher titres in Ae. aegypti maintained at constant temperature conditions. For ZIKV transmission to occur in Ae. aegypti, a disseminated virus load threshold of 7.59 log10 copies had to be reached. CONCLUSIONS/SIGNIFICANCE: Australian Ae. aegypti are better able to transmit a Brazilian ZIKV strain than Ae. albopictus. The results are in agreement with the global consensus that Ae. aegypti is the major vector of ZIKV.
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