Evidence map›Paper›PMID 30946637›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019

Delineating the age-related attenuation of vascular function: Evidence supporting the efficacy of the single passive leg movement as a screening tool.

Jay R Hydren, Ryan M Broxterman, Joel D Trinity, Jayson R Gifford, Oh Sung Kwon, Andrew C Kithas, Russell S Richardson

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jay R HydrenDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.ORCID 0000-0001-9385-8898
Ryan M BroxtermanGeriatric Research, Education, and Clinical Center, Salt Lake City Veteran Affairs Medical Center , Salt Lake City, Utah.
Joel D TrinityDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.
Jayson R GiffordDepartment of Internal Medicine, University of Utah , Salt Lake City, Utah.
Oh Sung KwonDepartment of Internal Medicine, University of Utah , Salt Lake City, Utah.
Andrew C KithasDepartment of Internal Medicine, University of Utah , Salt Lake City, Utah.
Russell S RichardsonDepartment of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.

Funding

Tissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WAGNER, PETER D · 2009 to 2013
$10.1M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Passive limb movement: A tool to assess vascular health and guide rehabilitationI01RX001697 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2015 to 2018
–
Vascular Endothelial Function: A Potential Therapeutic Target in Alzheimer's DiseaseI01RX002323 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2017 to 2024
–
Understanding the Exercise-Hypertension Paradox: Implication for RehabilitationIK2RX001215 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TRINITY, JOEL DOUGLAS · 2014 to 2018
–
NHLBI NIH HHS P01 HL091830NHLBI NIH HHS T32 HL139451RRD VA I01 RX001697RRD VA I01 RX002323RRD VA IK2 RX001215
6 · The paper itself

Abstract

Continuous passive leg movement (PLM) is a promising clinical assessment of the age-related decline in peripheral vascular function. To further refine PLM, this study evaluated the efficacy of a single PLM (sPLM), a simplified variant of the more established continuous movement approach, to delineate between healthy young and old men based on vascular function. Twelve young (26 ± 5 yr) and 12 old (70 ± 7 yr) subjects underwent sPLM (a single passive flexion and extension of the knee joint through 90°), with leg blood flow (LBF, common femoral artery with Doppler ultrasound), blood pressure (finger photoplethysmography), and leg vascular conductance (LVC) assessed. A receiver operator characteristic curve analysis was used to determine an age-specific cut score, and a factor analysis was performed to assess covariance. Baseline LBF and LVC were not different between groups (

Indexed as

AdultBlood PressureFemoral ArteryHumansHyperemiaLegMaleMiddle AgedMovementRegional Blood Flowcut scorehemodynamicsleg blood flowleg vascular conductance

Identifiers

PMID30946637
PMCPMC6620662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.