ReviewCurrent opinion in HIV and AIDS2019
Ethical issues in HIV phylogenetics and molecular epidemiology.
Review in Current opinion in HIV and AIDS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges in Elucidating HIV-1 Genetic Diversity in the Middle East and North Africa: A Review Based on a Systematic Search.Viruses · 2025Pooled it
- Use of HIV Phylogenetic Analysis in Public Health in Victoria, Australia: Regulatory Considerations.Journal of bioethical inquiry · 2026Article
- Statewide multi-year wastewater sequencing reveals dual origins of HIV-1 signal.Nature communications · 2026Article
- Community Perceptions Regarding use of HIV Molecular Epidemiology for Public Health in Victoria, Australia: Qualitative Findings.Journal of bioethical inquiry · 2026Article
- Tracking HIV Through Wastewater: Ethical Considerations in Public Health Surveillance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Phylogenetics and molecular evolution to understand and curb the HIV pandemic.Nature reviews. Microbiology · 2026Review
- Ethical considerations and the social context of HIV phylogenetic research in uMkhanyakude district, KwaZulu-Natal, South Africa.Southern African journal of HIV medicine · 2026Article
- More evidence is needed to improve molecular HIV surveillance for cluster detection and response.Communications medicine · 2025Article
- Ethics of Identifying Individuals Involved in HIV Transmission Events by Phylogenetics in Molecular Surveillance.Bioethics · 2025Article
- Risks, concerns, and benefits of molecular HIV Epidemiology in Public Health Practice: A qualitative exploration of perspectives among affected and interested communities.Journal of public health research · 2025Article
- Article
- Molecular HIV Surveillance: Beyond Cluster Detection and Response.AIDS research and human retroviruses · 2025Article
- Perceptions of Molecular HIV Surveillance Among Men Who Have Sex with Men in the United States.AIDS and behavior · 2025Article
- User experience with HIV molecular epidemiology in research, surveillance, and cluster detection and response: a needs assessment.Current medical research and opinion · 2024Article
- Prioritization of ethical concerns regarding HIV molecular epidemiology by public health practitioners and researchers.BMC public health · 2024Article
- Developing a reporting item checklist for studies of HIV drug resistance prevalence or incidence: a mixed methods study.BMJ open · 2024Article
- Recommendations on data sharing in HIV drug resistance research.PLoS medicine · 2023Article
- Brief Report: Challenges in Obtaining the Informed Perspectives of Stakeholders Regarding HIV Molecular Epidemiology.Journal of acquired immune deficiency syndromes (1999) · 2023Article
- Ending the HIV Epidemic: Identifying Barriers and Facilitators to Implement Molecular HIV Surveillance to Develop Real-Time Cluster Detection and Response Interventions for Local Communities.International journal of environmental research and public health · 2023Article
- Insights into HIV-1 Transmission Dynamics Using Routinely Collected Data in the Mid-Atlantic United States.Viruses · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewHIV phylogenetic and molecular epidemiology analyses are increasingly being performed with a goal of improving HIV prevention efforts. However, ethical, legal and social issues are associated with these analyses, and should be considered when performed. RECENT
findingsSeveral working groups have recently outlined the major issues surrounding the use of molecular epidemiology for HIV prevention. First, the benefits of HIV molecular epidemiology remain unclear, and further work is needed to quantitatively demonstrate the benefits that can be expected. Second, privacy loss is an important risk, with implications of disclosure varying by the regional legal and social climate. Inferential privacy risks will increase with technological improvements in sequencing and analysis. Third, data sharing, which enhances the utility of the data, may also increase the risk of inferential privacy loss. Mitigation strategies are available to address each of these issues. SUMMARY: HIV molecular epidemiology for research and public health pose significant ethical issues that continue to evolve with improving technology, increased sampling and a changing legal and social climate. Guidance surrounding these issues needs to be developed for researchers and public health officials in an iterative and region specific manner that accounts for the potential benefits and risks of this technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.