Evidence map›Paper›PMID 30946009›Full record

ArticleeLife2019

HIF-1α regulates IL-1β and IL-17 in sarcoidosis.

Jaya Talreja, Harvinder Talwar, Christian Bauerfeld, Lawrence I Grossman, Kezhong Zhang, Paul Tranchida, Lobelia Samavati

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Overview of multi-omics approaches for pulmonary sarcoidosis.EC pulmonology and respiratory medicine · 2025
    Article
  9. Review
  10. Discovery of Two Novel Immunoepitopes and Development of a Peptide-based Sarcoidosis Immunoassay.American journal of respiratory and critical care medicine · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Macrophage Biology in Human Granulomatous Skin Inflammation.International journal of molecular sciences · 2023
    Review
  18. LeveragingFrontiers in pharmacology · 2023
    Article
  19. Immune mechanisms in fibrotic pulmonary sarcoidosis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jaya TalrejaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States.ORCID 0000-0001-6557-6500
Harvinder TalwarDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States.
Christian BauerfeldDepartment of Pediatrics, Division of Critical Care, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States.
Lawrence I GrossmanCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, United States.
Kezhong ZhangCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, United States.
Paul TranchidaDepartment of Pathology, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States.
Lobelia SamavatiDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, United States.ORCID 0000-0002-3327-2585
Wayne State University · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
Regulation of Hepatic Steatosis by an ER Stress-Inducible Transcription Factor CRR01DK090313 · NIDDK · WAYNE STATE UNIVERSITY · PI Kezhong Zhang · 2011 to 2026
$5.0M
Role and Regulation of MKP-1 in SarcoidosisR01HL113508 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2013 to 2017
$1.9M
NCI NIH HHS P30 CA022453NHLBI NIH HHS R01 HL113508NHLBI NIH HHS R01HL113508NIDDK NIH HHS R01 DK090313U.S. Department of Defense W81XWH-16-1-0516Wayne State University Henry L Brasza endowment
6 · The paper itself

Abstract

Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14

Indexed as

Gene Expression RegulationAdolescentAdultFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitInflammationInterleukin-17Interleukin-1betaLungMacrophagesMaleMonocytesSarcoidosisTh17 CellsTh1 CellsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInterleukin-17Interleukin-1betaalveolar macrophagesHIF-1αhuman biologyIL-17IL-1βimmunologyinflammationmedicinemonocytesnonesarcoidosis

Identifiers

PMID30946009
PMCPMC6506207
OpenAlexW2932199720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.