Evidence map›Paper›PMID 30945967›Full record

SynthesisHuman vaccines & immunotherapeutics2019

Vaccination among HIV-infected, HIV-exposed uninfected and HIV-uninfected children: a systematic review and meta-analysis of evidence related to vaccine efficacy and effectiveness.

Olatunji O Adetokunboh, Duduzile Ndwandwe, Ajibola Awotiwon, Olalekan A Uthman, Charles S Wiysonge

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Olatunji O AdetokunbohCochrane South Africa, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0002-4608-3951
Duduzile NdwandweCochrane South Africa, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0001-7129-3865
Ajibola AwotiwonKnowledge Translation Unit, University of Cape Town Lung Institute, Cape Town, South Africa.ORCID 0000-0003-0887-8670
Olalekan A UthmanCochrane South Africa, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0002-8567-3081
Charles S WiysongeCochrane South Africa, South African Medical Research Council, Cape Town, South Africa.ORCID 0000-0002-1273-4779
South African Medical Research Council · ZAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence-based approaches were used in making recommendations for vaccination against vaccine-preventable diseases for HIV-infected and HIV-exposed individuals but with limited substantiation. We conducted a systematic review and meta-analysis with randomized-controlled trials (RCTs), cohort and case-control studies that have efficacy and effectiveness of vaccines in HIV-infected and HIV-exposed children as outcomes. Web of Science, Cochrane Library, PubMed and Scopus databases were searched for articles. Efficacy of 9-valent pneumococcal conjugate vaccine (PCV9) against total vaccine serotype invasive pneumococcal disease was 32% in HIV-infected children and 78% among HIV-uninfected children. Vaccine effectiveness of Bacillus Calmette-Guérin vaccine in preventing tuberculosis in HIV-infected children was zero compared to 59% protection in HIV-unexposed children. Likewise, HIV-uninfected children have better protection against invasive

Indexed as

Vaccine PotencyAdolescentAfrica South of the SaharaChildChild, PreschoolHIV InfectionsHumansInfantObservational Studies as TopicPneumococcal InfectionsPneumococcal VaccinesRandomized Controlled Trials as TopicTuberculosisTuberculosis VaccinesVaccinationPneumococcal VaccinesTuberculosis VaccineseffectivenessefficacyHIVsub-Saharan Africavaccine-preventable diseases

Identifiers

PMID30945967
PMCPMC6930074
OpenAlexW2935113741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.