Evidence map›Paper›PMID 30945459›Full record

ReviewAdvanced healthcare materials2019

Multifunctional Biomedical Adhesives.

Rattapol Pinnaratip, Mohammad Saleh Akram Bhuiyan, Kaylee Meyers, Rupak M Rajachar, Bruce P Lee

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. One-Pot Synthesis of Antibacterial and Antioxidant Self-Healing Bioadhesives Using Ugi Four-Component Reactions.Journal of biomedical materials research. Part B, Applied biomaterials · 2025
    Article
  8. Review
  9. Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. A 3D printable tissue adhesive.Nature communications · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rattapol PinnaratipDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
Mohammad Saleh Akram BhuiyanDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
Kaylee MeyersDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
Rupak M RajacharDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
Bruce P LeeDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.ORCID 0000-0002-6529-0032

Funding

Biomimetic Tissue Adhesive with Mechanically Tough Hydrogel SupportR15GM104846 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LEE, BRUCE P · 2013 to 2016
$757k
Adhesive PEG-fibrinogen nitric oxide releasing hydrogels for use as a wound healiR15GM112082 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI RAJACHAR, RUPAK M · 2015 to 2015
$326k
NIGMS NIH HHS R15 GM104846NIGMS NIH HHS R15 GM112082
6 · The paper itself

Abstract

Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self-healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.

Indexed as

Anti-Infective AgentsBiocompatible MaterialsTissue AdhesivesAnimalsHumansWound HealingAnti-Infective AgentsBiocompatible MaterialsTissue Adhesivesbiomedical adhesivesmultifunctionalitypassive and active designstimuli-responsiveness

Identifiers

PMID30945459
PMCPMC6636851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.