Evidence map›Paper›PMID 30945331›Full record

ReviewAmerican journal of hematology2019

Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia.

Bruno C Medeiros, Steven M Chan, Naval G Daver, Brian A Jonas, Daniel A Pollyea

Abstract readReview
In one paragraph

Review in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

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  7. Phase 1 Study of KITE-222, an Autologous CLL-1-Directed CAR T-cell Therapy in Patients with Relapsed/Refractory Acute Myeloid Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bruno C MedeirosDepartment of Hematology, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-6972-8137
Steven M ChanPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Naval G DaverDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-7103-373X
Brian A JonasUniversity of California Davis Comprehensive Cancer Center, Sacramento, California.
Daniel A PollyeaUniversity of Colorado School of Medicine, Aurora, Colorado.

Funding

Celgene Corporation
6 · The paper itself

Abstract

Optimization of post-remission therapies to maintain complete remission and prevent relapse is a major challenge in treating patients with acute myeloid leukemia (AML). Monitoring patients for measurable residual disease (MRD) is helpful to identify those at risk for relapse. Hypomethylating agents are being investigated as post-remission therapy. Identification of recurrent genetic alterations that drive disease progression has enabled the design of new, personalized approaches to therapy for patients with AML. Emerging data suggest that targeted post-remission therapy, alone or in combination with chemotherapy, may improve outcomes. Results of ongoing clinical trials will further define potential clinical benefits.

Indexed as

Remission InductionHumansLeukemia, Myeloid, AcuteNeoplasm, ResidualRecurrence

Identifiers

PMID30945331
PMCPMC6593671

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.