Evidence map›Paper›PMID 30945250›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

CellOrganizer: Learning and Using Cell Geometries for Spatial Cell Simulations.

Timothy D Majarian, Ivan Cao-Berg, Xiongtao Ruan, Robert F Murphy

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy D MajarianComputational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
Ivan Cao-BergComputational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
Xiongtao RuanComputational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
Robert F MurphyComputational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA. murphy@cmu.edu.

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Image-derived Spatiotemporal Models of Cellular Organization and PerturbationR01GM090033 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI MURPHY, ROBERT F, ROHDE, GUSTAVO KUNDE · 2010 to 2018
$2.4M
NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM090033
6 · The paper itself

Abstract

This chapter describes the procedures necessary to create generative models of the spatial organization of cells directly from microscope images and use them to automatically provide geometries for spatial simulations of cell processes and behaviors. Such models capture the statistical variation in the overall cell architecture as well as the number, shape, size, and spatial distribution of organelles and other structures. The different steps described include preparing images, learning models, evaluating model quality, creating sampled cell geometries by various methods, and combining those geometries with biochemical model specifications to enable simulations.

Indexed as

CellsComputer SimulationHumansImage Processing, Computer-AssistedMicroscopy, FluorescenceModels, BiologicalOrganellesBiochemical simulationGenerative modelSpatial organization

Identifiers

PMID30945250
PMCPMC6571027

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.