ReviewMolecular neurobiology2019
The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis.
Review in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- "Brain-First" vs. "Body-First" PD: Definitions and Implications in Everyday Clinical Practice: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Gut-brain-immune axis implications for mental health and disease.Molecular and cellular biochemistry · 2025Review
- Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis.Arthritis research & therapy · 2025Article
- Exploring Innovative Approaches for Managing Spinal Cord Injury: A Comprehensive Review of Promising Probiotics and Postbiotics.Probiotics and antimicrobial proteins · 2025Review
- Exploration of the Possible Relationships Between Gut and Hypothalamic Inflammation and Allopregnanolone: Preclinical Findings in a Post-Finasteride Rat Model.Biomolecules · 2025Article
- The Association Between Children's Dietary Inflammatory Index (C-DII) and Nutrient Adequacy with Gastrointestinal Symptoms, Sleep Habits, and Autistic Traits.Journal of autism and developmental disorders · 2025Article
- Article
- Alzheimer's Disease andLife (Basel, Switzerland) · 2025Review
- Neuroprotective Effect of a Multistrain Probiotic Mixture in SOD1Molecular neurobiology · 2024Article
- A novel on-a-chip system with a 3D-bioinspired gut mucus suitable to investigate bacterial endotoxins dynamics.Materials today. Bio · 2024Article
- Article
- Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators.Antioxidants (Basel, Switzerland) · 2023Review
- The neuromodulatory effects of flavonoids and gut Microbiota through the gut-brain axis.Frontiers in cellular and infection microbiology · 2023Review
- Anti-Amnesic Effect of Synbiotic Supplementation ContainingInternational journal of molecular sciences · 2022Article
- Dietary Polyphenols as Prospective Natural-Compound Depression Treatment from the Perspective of Intestinal Microbiota Regulation.Molecules (Basel, Switzerland) · 2022Review
- Bibliometric Visualization Analysis of Microbiome-Gut-Brain Axis from 2004 to 2020.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Bi-directional elucidation of Lactiplantibacillus plantarum (RTA 8) intervention on the pathophysiology of gut-brain axis during Salmonella brain infection.Gut pathogens · 2022Article
- Convergent pathways of the gut microbiota-brain axis and neurodegenerative disorders.Gastroenterology report · 2022Review
- Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis.Clinical & translational immunology · 2022Review
- The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review.Current research in neurobiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been shown that the gut microbiota plays a crucial role in the maintenance of intestinal homeostasis. Additionally, it has been demonstrated that dysbiosis is closely correlated with chronic intestinal inflammation, contributing to the development of chronic intestinal diseases, and also of brain pathologies, including neurodegenerative, neurodevelopmental, and psychiatric disorders. Given the paramount importance of gut microbiota for the establishment of communication between the gut and the brain, the microbiota-gut-brain axis has been increasingly explored within the scope of neurosciences. In this review article, we present an overview of key cellular signaling pathways underlying chronic intestinal inflammation and the influence of chronic intestinal inflammation and dysbiosis on brain disorders. This will include the presentation of valuable data from recent preclinical and clinical research. We will also address the importance of probiotics and prebiotics to targeting the microbiota-gut-brain axis in the context of some brain disorders, where they are seen to be promising strategies for ameliorating brain disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.