ArticleUpdates in surgery2019
Intraoperative verification of parathyroid glands in primary and secondary hyperparathyroidism using near-infrared autofluorescence (IOPA).
Article in Updates in surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Near-infrared autofluorescence-based parathyroid glands identification in the thyroidectomy or parathyroidectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2022Pooled it
- The Accuracy of Near Infrared Autofluorescence in Identifying Parathyroid Gland During Thyroid and Parathyroid Surgery: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- The Ability of Near-Infrared Autofluorescence to Protect Parathyroid Gland Function During Thyroid Surgery: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Near-infrared autofluorescence of the parathyroid glands during thyroidectomy for the prevention of hypoparathyroidism: a prospective randomized clinical trial.Langenbeck's archives of surgery · 2022Trial
- Identification of Parathyroid Glands Through Near-Infrared Autofluorescence During Thyroid Surgery: Retrospective Analysis of the Impact on Post-Operative Hypocalcemia Rate Reduction and Potential Improvement of Healthcare Expenditure.Medicina (Kaunas, Lithuania) · 2025Article
- Do stricter criteria for intraoperative parathyroid hormone monitoring reduce the risk of persistence or reoperation in primary hyperparathyroidism? A receiver operating characteristic analysis.Langenbeck's archives of surgery · 2025Article
- Article
- Preoperative identification of small parathyroid adenomas-better done by fluorocholine positron emission tomography/computed tomography.Gland surgery · 2023Article
- Treatment for secondary hyperparathyroidism focusing on parathyroidectomy.Frontiers in endocrinology · 2023Review
- Why does diseased parathyroid appear weak or heterogenous intensity during intraoperative near-infrared autofluorescence?Frontiers in endocrinology · 2023Article
- [Research progress of autofluorescence imaging of parathyroid glands].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Review
- Advances in the treatment of secondary and tertiary hyperparathyroidism.Frontiers in endocrinology · 2022Review
- Detecting the Near Infrared Autofluorescence of the Human Parathyroid: Hype or Opportunity?Annals of surgery · 2020Review
- Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative verification of parathyroid glands relies on visual identification by the surgeon and, with some time delay, on serum parathormon measurements and frozen section. Fluorescence imaging, however, is an instant on-table method for direct visualization of parathyroid tissue which is known to exhibit increased autofluorescence intensity when exposed to near-infrared light. In this retrospective observational study, we evaluate the clinical use of this method in a series of patients with primary and secondary hyperparathyroidism. A total of 66 adenomatous and hyperplastic parathyroid glands were examined with intraoperative autofluorescence in 39 patients with primary and secondary hyperparathyroidism using a near-infrared system (KARL STORZ GmbH & Co. KG). The specimens were verified by conventional histology. Fifty-seven of 66 histologically proven adenomatous/hyperplastic glands exhibited autofluorescence. The sensitivity of near-infrared autofluorescence was 0.9 in pHPT and 0.83 in sHPT, respectively. The positive predictive value was 0.93 in pHPT and 1.0 in sHPT, respectively. Near-infrared autofluorescence guidance presents an innovative instant surgical imaging tool with sensitivity in detecting adenomatous and hyperplastic parathyroid glands comparable to current intraoperative methods. Due to its elegant and tracer-free design combined with low follow-up costs, this method can be useful for routine use.
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