SynthesisInfection2019
A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery.
Synthesis in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Synthesizing evidence to guide the design and implementation of effective strategies for discontinuing postoperative antibiotic prophylaxis in surgical settings: an umbrella review post-WHO 2018 recommendations.Systematic reviews · 2025Pooled it
- Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials.Oral and maxillofacial surgery · 2020Pooled it
- Patient-reported outcome measures comparing povidone iodine rinse and chlorhexidine rinse for dental implant therapy: a randomized controlled trial.BMC oral health · 2025Trial
- Is perioperative antibiotic prophylaxis in the case of routine surgical removal of the third molar still justified? A randomized, double-blind, placebo-controlled clinical trial with a split-mouth design.Clinical oral investigations · 2022Trial
- Effect of antibiotic prophylaxis for preventing infectious complications following impacted mandibular third molar surgery. A randomized controlled trial.Medicina oral, patologia oral y cirugia bucal · 2021Trial
- Is single-shot antibiotic prophylaxis really enough for standard OMF-surgeries?Clinical oral investigations · 2026Article
- Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections.Advanced healthcare materials · 2026Article
- Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Antibiotic Prophylaxis and Postoperative Therapy in Tooth Extractions for Patients at Risk of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Factors associated with postoperative complications after orthognathic surgery - a National Swedish register-based cohort study.Oral and maxillofacial surgery · 2025Article
- The Importance of Antibiotics in Facial Fracture Treatment-A Systematic Meta-Review.Craniomaxillofacial trauma & reconstruction · 2025Review
- Rational utilization of antibiotic prophylaxis in oral and maxillofacial surgery: a large scope review of recent data.BMC oral health · 2025Review
- Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study.BMC oral health · 2025Article
- A Systematic Review on Prior/Postoperative Antibiotics Therapy Efficiency in Reducing Surgical Complications After Third Molar Extraction Surgery.Journal of maxillofacial and oral surgery · 2025Review
- Retrospective Analysis of Surgical Site Infection After Titanium Plate Removal Following Orthognathic Surgery.Journal of clinical medicine · 2025Article
- Risk Factors for Postsurgical Infections in Facial Feminization Surgery.Aesthetic plastic surgery · 2023Article
- Antibiotics Efficiency in the Infection Complications Prevention after Third Molar Extraction: A Systematic Review.Dentistry journal · 2022Review
- Systemic Antibiotic Prophylaxis in Maxillofacial Trauma: A Scoping Review and Critical Appraisal.Antibiotics (Basel, Switzerland) · 2022Article
- Winds of Change in Antibiotic Therapy following Orthognathic Surgery.Medicina (Kaunas, Lithuania) · 2022Article
- Inadvertent placement of a nasogastric tube following traumatic nasal tube intubation.BMJ case reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEspecially in oral and maxillofacial surgery, where procedures involving the aero-digestive tract considered clean contaminated, surgical site infections (SSI) represent a severe health care burden. To improve implementation and methodological standard, an upgrade of the existing S1 guideline to a consensus-guided S3 guideline was initiated by the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V., AWMF, register number 067/009) and 25 collaborating medical societies.
methodsA systematic literature search based on the Scottish Intercollegiate GL Network (SIGN)-search string for the guideline "Antibiotic prophylaxis in surgery" from 2014 was performed and equivalent exclusion/inclusion criteria were applied. An additional hand search provided latest evidence.
resultsIn total, 80 clinical trials, retrospective studies, reviews, and meta-analysis were analyzed. For orthognathic surgery, prolonged antibiotic regimen may reduce risk for SSI but there is lack of evidence for the effects of short- vs. long-term therapy. For maxillofacial traumatology, antibiotic prophylaxis might reduce SSI but prolonged postoperative dosing shows no benefit. For clean-contaminated oncological interventions, anti-infectious therapy for 24 h only can reduce SSI; patients may not benefit from prolonged regimen. In contrast, for dentoalveolar procedures such as implantology or third molar removal, literature reveals ambivalent results.
conclusionIn summary, consensus process of the planned S3 guideline is much in need to transfer the indecisive results for antibiotic prophylaxis in dentoalveolar surgery in clinical praxis and encourage adherence to guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.