Evidence map›Paper›PMID 30945100›Full record

ArticleEuropean radiology experimental2019

Timing optimization of low-dose first-pass analysis dynamic CT myocardial perfusion measurement: validation in a swine model.

Logan Hubbard, Shant Malkasian, Yixiao Zhao, Pablo Abbona, Sabee Molloi

Abstract readValidation Study
In one paragraph

Article in European radiology experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  6. A patient-specific timing protocol for improved CT pulmonary angiography.Research in diagnostic and interventional imaging · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Logan HubbardDepartment of Radiological Sciences, Medical Sciences I, B-140, University of California, Irvine, Irvine, CA, 92697, USA.
Shant MalkasianDepartment of Radiological Sciences, Medical Sciences I, B-140, University of California, Irvine, Irvine, CA, 92697, USA.
Yixiao ZhaoDepartment of Radiological Sciences, Medical Sciences I, B-140, University of California, Irvine, Irvine, CA, 92697, USA.
Pablo AbbonaDepartment of Radiological Sciences, Medical Sciences I, B-140, University of California, Irvine, Irvine, CA, 92697, USA.
Sabee MolloiDepartment of Radiological Sciences, Medical Sciences I, B-140, University of California, Irvine, Irvine, CA, 92697, USA. symolloi@uci.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Training Program in Cardiovascular Applied Research and EntrepreneurshipT32HL116270 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUGHES, CHRISTOPHER C. W. · 2013 to 2022
$1.6M
Anatomical and Functional Assessment of Coronary Artery Disease Using Whole-Heart Dynamic Computed TomographyF30HL137288 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUBBARD, LOGAN CHARLES · 2018 to 2020
$89k
NHLBI NIH HHS F30 HL137288NHLBI NIH HHS T32 HL116270NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

backgroundMyocardial perfusion measurement with a low-dose first-pass analysis (FPA) dynamic computed tomography (CT) perfusion technique depends upon acquisition of two whole-heart volume scans at the base and peak of the aortic enhancement. Hence, the objective of this study was to validate an optimal timing protocol for volume scan acquisition at the base and peak of the aortic enhancement.

methodsContrast-enhanced CT of 28 Yorkshire swine (weight, 55 ± 24 kg, mean ± standard deviation) was performed under rest and stress conditions over 20-30 s to capture the aortic enhancement curves. From these curves, an optimal timing protocol was simulated, where one volume scan was acquired at the base of the aortic enhancement while a second volume scan was acquired at the peak of the aortic enhancement. Low-dose FPA perfusion measurements (P

resultsP

conclusionsAn optimal timing protocol for volume scan acquisition at the base and peak of the aortic enhancement was retrospectively validated and has the potential to be used to implement an accurate, low-dose, FPA perfusion technique.

Indexed as

Tomography, X-Ray ComputedAnimalsModels, AnimalMyocardial Perfusion ImagingRadiation DosageSwineTime FactorsAnimal experimentationCoronary artery diseaseMyocardiumPerfusion imagingTomography (x-ray computed)

Identifiers

PMID30945100
PMCPMC6447643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.