Evidence map›Paper›PMID 30945071›Full record

ArticleInflammopharmacology2019

Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.

Mohammad Alsalem, Mansour Haddad, Sara A Aldossary, Heba Kalbouneh, Ahmad Altarifi, Sahar M Jaffal, Manal A Abbas, Nour Aldaoud, Khalid El-Salem

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  7. Article
  8. Article
  9. The Basal Pharmacology of Palmitoylethanolamide.International journal of molecular sciences · 2020
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mohammad AlsalemFaculty of Medicine, The University of Jordan, Amman, 11942, Jordan. m_alsalem@ju.edu.jo.ORCID http://orcid.org/0000-0001-5575-4377
Mansour HaddadFaculty of Pharmacy, Philadelphia University, Amman, Jordan.
Sara A AldossaryFaculty of Clinical Pharmacy, King Faisal University, Hofuf, Saudi Arabia.
Heba KalbounehFaculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
Ahmad AltarifiFaculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Sahar M JaffalFaculty of Science, The University of Jordan, Amman, 11942, Jordan.
Manal A AbbasFaculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Nour AldaoudFaculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
Khalid El-SalemFaculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
University of Jordan · JOJordan University of Science and Technology · JOAl-Ahliyya Amman University · JOKing Faisal University · SAPhiladelphia University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is characterized by cartilage degeneration, subchondral sclerosis, and pain. Cannabinoids have well-established anti-nociceptive properties in animal models of chronic pain. The aim of this study is to evaluate the anti-nociceptive effects of synthetic cannabinoids (WIN-55,212 and HU210) and the cannabinoid-like compound palmitoylethanolamide (PEA) in rat models of OA and to assess the role of cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor α (PPARα) in mediating these effects. Intra-articular injection of monosodium iodoacetate (MIA) in the knee joint was used as a model of osteoarthritis. The von Frey filament test and weight-bearing difference were used to assess the anti-nociceptive effects of WIN-55,212, HU210, and PEA on MIA-induced OA in rats. Open-field locomotor activity system was used confirm the analgesic effects of those compounds. HU210, WIN55, 212, and PEA in a dose-dependent manner restored the paw withdrawal threshold (PWT) and the weight-bearing difference induced by MIA injection. SR141716A (a CB1 antagonist) significantly reversed the anti-nociceptive effects of all the administered drugs in terms of PWT. However, in terms of weight-bearing difference, SR141716A significantly reduced the anti-nociceptive effect of HU210 but not PEA or WIN55, 212. GW6471 (a PPARα antagonist) significantly reversed the anti-nociceptive effects of PEA but not those of HU210 or WIN55, 212. HU210, WIN55, 212 and PEA significantly restored the MIA-induced reduction in locomotor activity. In conclusions, both CB1 and PPARα receptors are involved in mediating pain in osteoarthritis. Therefore, targeting these receptors may be of great clinical value.

Indexed as

AmidesAnalgesicsAnimalsCannabinoidsDronabinolEthanolaminesIodoacetic AcidMaleMotor ActivityOsteoarthritisOxazolesPalmitic AcidsPPAR alphaRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1AmidesAnalgesicsCannabinoidsDronabinolEthanolaminesGW 6471HU 211Iodoacetic AcidOxazolespalmidrolPalmitic AcidsPPAR alphaReceptor, Cannabinoid, CB1RimonabantTyrosineCannabinoid receptor 1OsteoarthritisPainPeroxisome proliferator-activated receptor α

Identifiers

PMID30945071
OpenAlexW2932474518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.