ArticleActa neuropathologica2019
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Acta neuropathologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.Biomolecules · 2022Pooled it
- ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities.Cellular & molecular biology letters · 2026Review
- Cortical free-water imaging in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants.Research square · 2026Article
- RNA modifications in health and disease: from mechanistic insights to therapeutic applications.Precision clinical medicine · 2025Review
- Review
- Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.bioRxiv : the preprint server for biology · 2025Article
- RNA dysregulation in neurodegenerative diseases.The EMBO journal · 2025Review
- ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation.Nucleic acids research · 2024Article
- RNA editing regulates glutamatergic synapses in the frontal cortex of a molecular subtype of Amyotrophic Lateral Sclerosis.Molecular medicine (Cambridge, Mass.) · 2024Article
- Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration.International journal of molecular sciences · 2024Review
- Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis.Current neuropharmacology · 2024Review
- Epigenetics in the formation of pathological aggregates in amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024Review
- RNA-Binding Proteins: A Role in Neurotoxicity?Neurotoxicity research · 2023Review
- The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.Molecular neurodegeneration · 2023Article
- The Fragile X Protein Family in Amyotrophic Lateral Sclerosis.Molecular neurobiology · 2023Review
- Review
- Moderate intrinsic phenotypic alterations inFrontiers in cellular neuroscience · 2023Article
- Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting.Frontiers in molecular neuroscience · 2023Article
- The Fault in Our Astrocytes - cause or casualties of proteinopathies of ALS/FTD and other neurodegenerative diseases?Frontiers in molecular medicine · 2023Review
- RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation.Nucleic acids research · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
18 authors at 7 institutions in 2 countries.
Stephen MooreDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Eric AlsopNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Ileana LorenziniDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Alexander StarrDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Benjamin E RabichowDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Emily MendezDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Jennifer L LevyDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Camelia BurciuDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
Rebecca ReimanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Jeannie ChewDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Veronique V BelzilDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Janice RobertsonTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.
Kim A StaatsDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Justin K IchidaDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Kendall Van Keuren-JensenNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Rita SattlerDepartment of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA. Rita.Sattler@Dignityhealth.org.
Barrow Neurological Institute · USTranslational Genomics Research Institute · USJacksonville College · USMayo Clinic in Florida · USUniversity of Southern California · USArizona State University · USOccupational Cancer Research Centre · CA
Funding
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MExpanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6MValidation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker developmentP01NS099114 · NINDS · UNIVERSITY OF FLORIDA · PI ROTHSTEIN, JEFFREY D · 2017 to 2021
$6.5MValidating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTDR01NS097850 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA · 2016 to 2024
$5.5MALS/FTD mutant C9orf72-induced genetic and nuclear pathology in iPS cell modelsR01NS085207 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROTHSTEIN, JEFFREY D, SATTLER, RITA · 2013 to 2017
$1.8MSilencing C9or72 with rAAV Mediated RNAiR01NS088689 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BROWN, ROBERT H., MUELLER, CHRISTIAN · 2014 to 2017
$1.6MNINDS NIH HHS P01 NS084974NINDS NIH HHS P01 NS099114NINDS NIH HHS R01 NS085207NINDS NIH HHS R01 NS088689NINDS NIH HHS R01 NS097850NINDS NIH HHS R35 NS097273U.S. Department of Defense W81XWH-15-1-0187
Abstract
The hexanucleotide repeat expansion GGGGCC (G
Indexed as
Adenosine DeaminaseAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinDNA Repeat ExpansionFrontotemporal DementiaHumansInduced Pluripotent Stem CellsMice, TransgenicPick Disease of the BrainRNA-Binding ProteinsRNA EditingADAR2 protein, mouseADARB1 protein, humanAdenosine DeaminaseC9orf72 ProteinC9orf72 protein, humanC9orf72 protein, mouseRNA-Binding ProteinsADAR2ALSC9orf72FTDiPSC neuronsNeurodegenerationNucleocytoplasmic mislocalizationProtein accumulationRNA editingRNA metabolismRNA-seq
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.