Evidence map›Paper›PMID 30944974›Full record

ArticleCellular and molecular life sciences : CMLS2019

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

Kyoung-In Cho, Dosuk Yoon, Minzhong Yu, Neal S Peachey, Paulo A Ferreira

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Sensory Involvement in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2022
    Review
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  8. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kyoung-In ChoDepartment of Ophthalmology, Duke University Medical Center, DUEC 3802, 2351 Erwin Road, Durham, NC, 27710, USA.
Dosuk YoonDepartment of Ophthalmology, Duke University Medical Center, DUEC 3802, 2351 Erwin Road, Durham, NC, 27710, USA.
Minzhong YuDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Neal S PeacheyDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Paulo A FerreiraDepartment of Ophthalmology, Duke University Medical Center, DUEC 3802, 2351 Erwin Road, Durham, NC, 27710, USA. paulo.ferreira@duke.edu.ORCID http://orcid.org/0000-0003-4585-1717
Cleveland Clinic · USDuke Medical Center · USDuke University · US

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Genetic and Molecular Analyses of Protein Biogenesis in the NeuroretinaR01EY019492 · NEI · DUKE UNIVERSITY · PI FERREIRA, PAULO A · 2010 to 2013
$1.5M
Genetic and Molecular Dissection of RanBP2-Mediated RanGTPase FunctionsR01GM083165 · NIGMS · DUKE UNIVERSITY · PI FERREIRA, PAULO A · 2010 to 2013
$1.4M
BLRD VA IK6 BX005233NEI NIH HHS EY019492NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY019492NIGMS NIH HHS GM083165NIGMS NIH HHS GM083165-03S1NIGMS NIH HHS R01 GM083165
6 · The paper itself

Abstract

Nucleocytoplasmic transport is dysregulated in sporadic and familial amyotrophic lateral sclerosis (ALS) and retinal ganglion neurons (RGNs) are purportedly involved in ALS. The Ran-binding protein 2 (Ranbp2) controls rate-limiting steps of nucleocytoplasmic transport. Mice with Ranbp2 loss in Thy1

Indexed as

Acetyl-CoA CarboxylaseActive Transport, Cell NucleusAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalEvoked PotentialsGene Expression RegulationLipid MetabolismMatrix Metalloproteinases, SecretedMiceMice, KnockoutMicrogliaMolecular ChaperonesMotor NeuronsNuclear Pore Complex ProteinsOptic NerveACC1 protein, mouseAcetyl-CoA CarboxylaseMatrix Metalloproteinases, SecretedMmp28 protein, mouseMolecular ChaperonesNuclear Pore Complex Proteinsran-binding protein 2TamoxifenThy-1 AntigensAcetyl-CoA carboxylase 1 (Acc1)Amyotrophic lateral sclerosis (ALS)Metalloproteinase-28 (Mmp28)MicrogliaNucleocytoplasmic transportRan-binding protein 2 (Ranbp2)Retinal ganglion neurons

Identifiers

PMID30944974
PMCPMC6698218
OpenAlexW2905808113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.