Evidence map›Paper›PMID 30944935›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2019

ALIX increases protein content and protective function of iPSC-derived exosomes.

Ruiting Sun, Yingying Liu, Meng Lu, Qianqian Ding, Pingping Wang, Heng Zhang, Xiaoyu Tian, Peng Lu, Dan Meng, Ning Sun and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  6. Extracellular vesicles: key mediators inFrontiers in veterinary science · 2025
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  7. FishJournal of virology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ruiting SunDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Yingying LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Meng LuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Qianqian DingDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Pingping WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Heng ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Xiaoyu TianDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Peng LuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Dan MengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Ning SunDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China.
Meng XiangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China. xmeng@shmu.edu.cn.
Sifeng ChenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dong-An Road, Building 7, Room 214, Shanghai, 200032, China. chen1216@fudan.edu.cn.ORCID 0000-0002-9504-5863
Fudan University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nature of exosome-secreting cells determines exosome content and function. ALIX, involved in exosome biogenesis, promotes cell degeneration. Here, ALIX was knocked out (iPSC-ALIX

Indexed as

AnimalsAortaBase SequenceCalcium-Binding ProteinsCell Cycle ProteinsCell MovementCisplatinEndosomal Sorting Complexes Required for TransportExosomesHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideInduced Pluripotent Stem CellsMiceNeovascularization, PhysiologicProtective AgentsCalcium-Binding ProteinsCell Cycle ProteinsCisplatinEndosomal Sorting Complexes Required for TransportHydrogen PeroxidePDCD6IP protein, humanProtective AgentsRNA, Small InterferingSNX2 protein, humanSorting NexinsApoptosis-linked gene 2–interacting protein XEndosomal proteomicsEndothelial cellsExosomeInduced pluripotent stem cells

Identifiers

PMID30944935
OpenAlexW2927201626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.