Evidence map›Paper›PMID 30944902›Full record

ReviewActa myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology2018

The role of rehabilitation in the management of late-onset Pompe disease: a narrative review of the level of evidence.

Giovanni Iolascon, Michele Vitacca, Elena Carraro, Carmelo Chisari, Pietro Fiore, Sonia Messina, Tiziana Enrica Giovanna Mongini, Valeria A Sansone, Antonio Toscano, Gabriele Siciliano

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05951790 (Efficacy and Feasibility of Inspiratory Muscle Training), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05951790 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy and Feasibility of Inspiratory Muscle Training (IMT) in Adult People With Pompe Disease: a Multicentre, Cross-over Randomized Control Trial (RCT)

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2024Enrolled20ConditionsGlycogen Storage Disease Type II, Pompe Disease (Late-onset)ArmsInspiratory Muscle Training (IMT), Inspiratory Muscle Training (IMT) + Air Stacking
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Management of Pompe disease alongside and beyond ERT: a narrative review.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Adapted physical activity and therapeutic exercise in late-onset Pompe disease (LOPD): a two-step rehabilitative approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  7. Exercise therapy in muscle diseases: open issues and future perspectives.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Giovanni IolasconDepartment of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Michele VitaccaFERS Respiratory Rehabilitative Unit ICS S. Maugeri IRCCS Lumezzane (Bs) Italy.
Elena CarraroNeuromuscular Omnicentre, Fondazione Serena Onlus, Milan, Italy.
Carmelo ChisariUnit of Neurorehabilitation, Department of Medical Specialties, University Hospital of Pisa, Italy.
Pietro FioreDepartment of Basic Sciences, Neuroscience and Sense Organs, University "Aldo Moro", Bari, Italy.
Sonia MessinaDepartment of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center, Messina, Italy.
Tiziana Enrica Giovanna MonginiNeuromuscular Center, AOU Città della Salute e della Scienza, University of Turin, Italy.
Valeria A SansoneNeurorehabilitation Unit, University of Milan, The Nemo Clinical Center, Milan, Italy.
Antonio ToscanoDepartment of Neurosciences, University of Messina, Italy.
Gabriele SicilianoDepartment of Clinical and Experimental Medicine, University of Pisa, Italy.
University of Messina · ITAzienda Ospedaliera Universitaria Pisana · ITCentro Clinico Nemo · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset Pompe disease (LOPD) is characterized by progressive muscle weakness, respiratory muscle dysfunction, and minor cardiac involvement. Although in LOPD, as in other neuromuscular diseases, controlled low impact sub-maximal aerobic exercise and functional ability exercise can improve general functioning and quality of life, as well as respiratory rehabilitation, the bulk of evidence on that is weak and guidelines are lacking. To date, there is no specific focus on rehabilitation issues in clinical recommendations for the care of patients with Pompe disease, and standard practice predominantly follows general recommendation guidelines for neuromuscular diseases. The Italian Association of Myology, the Italian Association of Pulmonologists, the Italian Society of Neurorehabilitation, and the Italian Society of Physical Medicine and Rehabilitation, have endorsed a project to formulate recommendations on practical, technical, and, whenever possible, disease-specific guidance on rehabilitation procedures in LOPD, with specific reference to the Italian scenario. In this first paper, we review available evidence on the role of rehabilitation in LOPD patients, particularly addressing the unmet needs in the management of motor and respiratory function for these patients.

Indexed as

Glycogen Storage Disease Type IIMotor SkillsQuality of LifeRespirationActivities of Daily LivingAge of OnsetExercise TherapyHumansItalyendurance and resistance traininglate-onset Pompe diseasemotor functionrehabilitationrespiratory function

Identifiers

PMID30944902
PMCPMC6416696
OpenAlexW2916044494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.