Evidence map›Paper›PMID 30944686›Full record

Trial reportPain research & management

Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial.

Meijuan Yang, Luyang Wang, Hong Chen, Yuwen Tang, Xinzhong Chen

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meijuan YangDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, Zhejiang 310006, China.
Luyang WangDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, Zhejiang 310006, China.
Hong ChenDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, Zhejiang 310006, China.
Yuwen TangDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, Zhejiang 310006, China.ORCID 0000-0001-8923-8784
Xinzhong ChenDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, Zhejiang 310006, China.ORCID 0000-0001-9219-1681
Women's Hospital, School of Medicine, Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSingle dose of epidural hydromorphone has been introduced to serve as an alternative method for postcesarean section analgesia. However, optimal dose of epidural hydromorphone remains unknown. Hence, we evaluated and compared the analgesic and adverse effects of postoperative different doses of epidural hydromorphone coadministered with ropivacaine after cesarean section.

methodsEighty term parturients with elective cesarean section under epidural anesthesia were allocated into four groups. Epidural analgesia was administered with an epidural bolus of either 0 mg (group H0), or 0.2 mg (group H1), or 0.4 mg (group H2), or 0.6 mg (group H3) hydromorphone coadministered with ropivacaine. The primary outcome was the visual analogue pain scores (VAPSs) and rescue opioid consumption (PCIA with sulfentanil) in 24 hours. Adverse effects such as respiratory depression, pruritus, nausea, and vomiting were recorded.

resultsThe VAPSs of group H1 at 2, 4, 6, 12 h and 24 h after surgery was similar to group H0. The VAPSs of group H2 at 4 and 6 h postoperatively were significantly decreased when compared to group H0. But, the VAPSs of group H2 at 2, 12, and 24 h postoperatively were similar to those of group H0. The VAPSs of group H3 at 4, 6, 12 h, and 24 h after surgery were significantly decreased when compared to those of group H0. The total sulfentanil consumption in 24 hours was 90 ± 26

conclusionsEpidural administration of 0.6 mg hydromorphone coadministered with ropivacaine after cesarean section provided satisfactory pain relief with less sulfentanil consumption. This trial is registered with ChiCTR-IPR-16010026.

Indexed as

Cesarean SectionAdultAnalgesia, EpiduralAnalgesicsDouble-Blind MethodFemaleHumansHydromorphoneMiddle AgedPatient SatisfactionPostoperative PainPregnancyRopivacaineTreatment OutcomeYoung AdultAnalgesicsHydromorphoneRopivacaine

Identifiers

PMID30944686
PMCPMC6421812
OpenAlexW2918462492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.