Evidence map›Paper›PMID 30944615›Full record

ArticleOncology letters2019

Natural killer cell monitoring in cutaneous melanoma - new dynamic biomarker.

Gheorghița Isvoranu, Mihaela Surcel, Radu-Ionuț Huică, Adriana Narcisa Munteanu, Ioana Ruxandra Pîrvu, Dan Ciotaru, Carolina Constantin, Ovidiu Bratu, Monica Neagu, Cornel Ursaciuc

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Therapeutic potential of interleukin-15 in cancer (Review).Experimental and therapeutic medicine · 2021
    Review
  5. Article
  6. Article
  7. Metabolic Traits in Cutaneous Melanoma.Frontiers in oncology · 2020
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gheorghița IsvoranuAnimal Husbandry, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Mihaela SurcelImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Radu-Ionuț HuicăImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Adriana Narcisa MunteanuImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Ioana Ruxandra PîrvuImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Dan CiotaruImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Carolina ConstantinImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Ovidiu BratuClinical Department 3, Central Military Hospital, 010825 Bucharest, Romania.
Monica NeaguImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Cornel UrsaciucImmunobiology Laboratory, 'Victor Babeș' National Institute of Pathology, 050096 Bucharest, Romania.
Institutul National Victor Babes · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is responsible for most skin cancer deaths in humans. The immune system plays a major role in regulating tumor cell proliferation by initiating defence responses against tumor aggression. Research on murine cancer models allow for a better understanding of immune response in malignancies, revealing specific changes of the immune status in the presence of tumors. Melanoma resistance to conventional therapies and its high immunogenicity justify the development of new therapies. These features reinforce melanoma as a suitable model for studying antitumor immunity. Recent findings on NK cell activation in cancer patients indicate that several important parameters, such as tumor capacity to modulate the function and phenotype of NK cells, require consideration for the choice of an NK-based therapy. In this study, we investigated T-CD4

Indexed as

B-lymphocytesmelanomaNK cellsT-lymphocytestumor-bearing mice

Identifiers

PMID30944615
PMCPMC6444282
OpenAlexW2916608689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.