Evidence map›Paper›PMID 30944552›Full record

ArticleDose-response : a publication of International Hormesis Society

Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model.

Li Yan Dai, Ren Hua Huang, Yun Zhou, Heng le Gu, Yong Bin Wang, Ching Chong Jack Yang, Xin Xu, Ming Ye, Yong Rui Bai, Yu Long Liu and 2 more

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In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li Yan DaiDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-2311-2916
Ren Hua HuangDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Yun ZhouShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Heng le GuDepartment of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Yong Bin WangDepartment of Biochemistry and Molecular Cell Biology, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Ching Chong Jack YangDepartment of Radiation Oncology, Monmouth Medical Center, Barnabas Health, Long Branch, NJ, USA.
Xin XuDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Ming YeDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Yong Rui BaiDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Yu Long LiuDepartment of Nuclear Accident Medical Emergency, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Xiao Bo LiDepartment of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
Xiu Mei MaDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to develop a novel dose conversion platform by improving linear-quadratic (LQ) model to more accurately describe radiation response for high fraction/acute doses. This article modified the LQ model via piecewise fitting the biological dose curve using different fractionated dose and optimizing the consistency between mathematical model and experimental data to gain a more reasonable transform. That mathematical development of the LQ model further amended certain deviations of various cell curves with high doses and implied the rationality of the present model at low dose range. The modified biologically effective dose model that solved the dilemma of inaccurate LQ model had been used in comparing between hypofractionated and conventional fractioned dose. It has been verified that the calculated values are similar in the treatment of same efficacy, no matter what α/β is, and provided a more rational explanation for significant differences among various hypofractionations. The equivalent uniform dose based on the subsection function could represent arbitrary inhomogeneous dose distributions including high-dose fractions, providing a foundation for the implementation of detailed evaluation of different cell dose effects.

Indexed as

biologically effective dose (BED)dose conversionequivalent uniform dose (EUD)linear-quadratic (LQ) modelstereotactic body radiation therapy (SBRT)

Identifiers

PMID30944552
PMCPMC6440057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.