Evidence map›Paper›PMID 30944364›Full record

ArticleScientific reports2019

In vitro neuronal network activity as a new functional diagnostic system to detect effects of Cerebrospinal fluid from autoimmune encephalitis patients.

Henner Koch, Cristina E Niturad, Stephan Theiss, Christian G Bien, Christian Elger, Klaus-Peter Wandinger, Angela Vincent, Michael Malter, Peter Körtvelyessy, Holger Lerche and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Henner KochDepartment of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Cristina E NituradDepartment of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Stephan TheissInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Christian G BienKrankenhaus Mara, Epilepsy Center Bethel, Bielefeld, Germany.
Christian ElgerDepartment of Epileptology, University Bonn Medical Center, Bonn, Germany.ORCID http://orcid.org/0000-0002-2531-6701
Klaus-Peter WandingerDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Angela VincentNeuroimmunology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Michael MalterDepartment of Neurology, University Hospital, Cologne, Germany.
Peter KörtvelyessyGerman Center for Neurodegenerative Diseases, University Hospital Magdeburg, Magdeburg, Germany.
Holger LercheDepartment of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany. henner.koch@uni-tuebingen.de.
Marcel DihnéDepartment of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany. marcel.dihne@interwaysmail.com.
Hertie Institute for Clinical Brain Research · DEEvangelisches Krankenhaus Bielefeld · DEGerman Center for Neurodegenerative Diseases · DEHeinrich Heine University Düsseldorf · DEJohn Radcliffe Hospital · GBUniversity Hospital Cologne · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intent of this study was to investigate if cerebrospinal fluid (CSF) from autoimmune encephalitis (AE) patients regulates in vitro neuronal network activity differentially to healthy human control CSF (hCSF). To this end, electrophysiological effects of CSF from AE patients or hCSF were measured by in vitro neuronal network activity (ivNNA) recorded with microelectrode arrays (MEA). CSF from patients with either N-methyl-D-aspartate-receptor-antibody (pCSF

Indexed as

2-Amino-5-phosphonovalerateAnimalsAnti-N-Methyl-D-Aspartate Receptor EncephalitisCerebrospinal FluidEncephalitisFemaleHashimoto DiseaseHumansMaleMiceMiddle AgedNervous SystemNeuronsPregnancyReceptors, N-Methyl-D-Aspartate2-Amino-5-phosphonovalerateReceptors, N-Methyl-D-Aspartate

Identifiers

PMID30944364
PMCPMC6447720
OpenAlexW2933103315

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.