ArticleScientific reports2019
Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Enhancement of vitamin BMicrobial cell factories · 2024Article
- Understanding the factors regulating host-microbiome interactions usingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- What happens to Bifidobacterium adolescentis and Bifidobacterium longum ssp. longum in an experimental environment with eukaryotic cells?BMC microbiology · 2024Article
- High genetic diversity and different type VI secretion systems in Enterobacter species revealed by comparative genomics analysis.BMC microbiology · 2024Article
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- Microbes are potential key players in the evolution of life histories and aging inEcology and evolution · 2023Article
- Characterization of Eight Bacterial Biosensors for Microbial Diagnostic and Therapeutic Applications.ACS synthetic biology · 2022Article
- Comparative transmission of bacteria from Artemia salina and Brachionus plicatilis to the cnidarian Nematostella vectensis.FEMS microbiology ecology · 2022Article
- Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging.Microbiology spectrum · 2021Article
- Article
- Effects of FUdR on gene expression in the C. elegans bacterial diet OP50.BMC research notes · 2021Article
- C. elegans: A biosensor for host-microbe interactions.Lab animal · 2021Review
- Host Immunity Alters Community Ecology and Stability of the Microbiome in a Caenorhabditis elegans Model.mSystems · 2021Article
- WormPaths:bioRxiv : the preprint server for biology · 2020Article
- Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine.BMC pharmacology & toxicology · 2020Article
- Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-ResistantMicroorganisms · 2020Article
- The Gut-Eye Axis: Lessons Learned from Murine Models.Ophthalmology and therapy · 2020Review
- Caenorhabditis elegans: a model to understand host-microbe interactions.Cellular and molecular life sciences : CMLS · 2020Review
- A systematic strategy for the investigation of vaccines and drugs targeting bacteria.Computational and structural biotechnology journal · 2020Review
- Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies.Mediators of inflammation · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The interactions between a host and its resident microbes form complicated networks that can affect host physiology. Disentangling these host-microbe interactions can help us better understand mechanisms by which bacteria affect hosts, while also defining the integral commensal protection that host-associated microbiota offer to promote health. Here we utilize a tractable genetic model organism, Caenorhabditis elegans, to study the effects of host environments on bacterial gene expression and metabolic pathways. First, we compared the transcriptomic profiles of E. coli OP50 in vitro (on agar plates) versus in vivo (fed to C. elegans host). Our data revealed that 110 biosynthetic genes were enriched in host-associated E. coli. Several of these expressed genes code for the precursors and products needed for the synthesis of lipopolysaccharides (LPS), which are important for innate immune and stress responses, as well as pathogenicity. Secondly, we compared the transcriptomic profiles of E. coli fed to hosts with different genetic backgrounds, including the long-lived daf-2/insulin like growth factor (IGF) receptor and short lived daf-16/FOXO transcription factor mutants. We find that hosts genetics also alters bacterial metabolic pathways. Given that bacteria influence host health, this transcriptomics approach can elucidate genes mediating host aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.