ArticleNature communications2019
NKG2A is a NK cell exhaustion checkpoint for HCV persistence.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 141 citations in OpenAlex.
- Upregulation of CCR4 in activated CD8European journal of immunology · 2021Trial
- Natural killer cells against viral infection: from basic biology to immunotherapy.Precision clinical medicine · 2026Review
- Integrative transcriptomic profiling reveals NK cell exhaustion-associated prognostic genes and identifies CSF1 as a key immunoregulatory target in hepatocellular carcinoma.Biology direct · 2026Article
- Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions.MedComm · 2026Review
- TIGIT impairs NK cell antifibrotic activity through the IFNγ-IFI30 axis in schistosomiasis-induced liver fibrosis.Frontiers in immunology · 2026Article
- The inhibitory receptor NKG2A is expressed on T-cells during BKPyVANephropathy.Frontiers in immunology · 2026Article
- Immune checkpoint inhibitors in infectious diseases: therapeutic reinvigoration, immunopathology, and precision targeting.Frontiers in immunology · 2026Review
- Identification of CD159A as a prognostic and immune biomarker in kidney renal clear cell carcinoma.Scientific reports · 2025Article
- Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host.Cellular and molecular life sciences : CMLS · 2025Article
- LAG3 Marks Activated but Hyporesponsive NK Cells.European journal of immunology · 2025Article
- Review
- The mechanisms and clinical significance of CD8Cancer biology & medicine · 2025Review
- Efficacy and safety of azvudine versus nirmatrelvir/ritonavir in cancer patients with COVID-19.Scientific reports · 2025Article
- The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions.MedComm · 2025Review
- Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa.Nature communications · 2025Article
- Inflammatory, Functional, and Compositional Changes of the Uterine Immune Microenvironment in a Lymphangioleiomyomatosis Mouse Model.Journal of cellular immunology · 2025Article
- Nanomaterials-mediated adenosine pathway inhibition for strengthening cancer immunotherapy.Theranostics · 2025Review
- Article
- Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study.Arthritis research & therapy · 2024Article
- Mechanisms of Cbl-Mediated Ubiquitination of Proteins in T and Natural Killer Cells and Effects on Immune Cell Functions.Life (Basel, Switzerland) · 2024Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 7 institutions in 1 country.
Chao ZhangThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Xiao-Mei WangDepartment of Hepatology, The First Hospital of Jilin University, 130021, Changchun, Jilin, China.
Shu-Ran LiThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Trix TwelkmeyerThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Wei-Hong WangThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Sheng-Yuan ZhangThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Shu-Feng WangInstitute of Immunology, The Third Military Medical University, 400038, Chongqing, China.
Ji-Zheng ChenThe State Key Laboratory of Virology and Center for Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.
Xia JinThe Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 200031, Shanghai, China.
Yu-Zhang WuInstitute of Immunology, The Third Military Medical University, 400038, Chongqing, China.
Xin-Wen ChenThe State Key Laboratory of Virology and Center for Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China.
Sheng-Dian WangThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Jun-Qi NiuDepartment of Hepatology, The First Hospital of Jilin University, 130021, Changchun, Jilin, China.
Hai-Rong ChenThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. hairong.chen@ibp.ac.cn.
Hong TangThe Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. htang@ips.ac.cn.
Chinese Academy of Sciences · CNArmy Medical University · CNInstitut Pasteur of Shanghai · CNUniversity of Chinese Academy of Sciences · CNFirst Hospital of Jilin University · CNInstitute of Biophysics · CNJilin University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exhaustion of cytotoxic effector natural killer (NK) and CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesCytokinesDisease Models, AnimalHepacivirusHepatitis C, ChronicHepatocytesHistocompatibility Antigens Class IInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMembrane ProteinsMiceNK Cell Lectin-Like Receptor Subfamily CRandom AllocationCytokinesHistocompatibility Antigens Class IInterferon-gammaMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily CQ surface antigens
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.