Evidence map›Paper›PMID 30944304›Full record

ArticleNature communications2019

Perinatal factors affect the gut microbiota up to four years after birth.

Fiona Fouhy, Claire Watkins, Cian J Hill, Carol-Anne O'Shea, Brid Nagle, Eugene M Dempsey, Paul W O'Toole, R Paul Ross, C Anthony Ryan, Catherine Stanton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 9 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 9 syntheses or guidelines pooled it, 258 citations in OpenAlex.

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  10. Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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  13. Oral Microbiome Characteristics in Patients With Autoimmune Hepatitis.Frontiers in cellular and infection microbiology · 2021
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  18. Article
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Fiona FouhyAPC Microbiome Ireland, Cork, T12 YT20, Ireland.ORCID http://orcid.org/0000-0002-8285-7694
Claire WatkinsAPC Microbiome Ireland, Cork, T12 YT20, Ireland.
Cian J HillAPC Microbiome Ireland, Cork, T12 YT20, Ireland.
Carol-Anne O'SheaDepartment of Neonatology, Cork University Maternity Hospital, Cork, T12 YE02, Ireland.
Brid NagleTeagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, P61 C996, Ireland.
Eugene M DempseyDepartment of Neonatology, Cork University Maternity Hospital, Cork, T12 YE02, Ireland.
Paul W O'TooleAPC Microbiome Ireland, Cork, T12 YT20, Ireland.
R Paul RossAPC Microbiome Ireland, Cork, T12 YT20, Ireland.
C Anthony RyanAPC Microbiome Ireland, Cork, T12 YT20, Ireland.
Catherine StantonAPC Microbiome Ireland, Cork, T12 YT20, Ireland. catherine.stanton@teagasc.ie.
Teagasc - The Irish Agriculture and Food Development Authority · IEAPC Microbiome Institute · IECork University Hospital · IEUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.

Indexed as

Anti-Bacterial AgentsBacteriaChild, PreschoolFecesFemaleGastrointestinal MicrobiomeGastrointestinal TractHumansInfantInfant, NewbornMaleMicrobiotaPregnancyPremature BirthRNA, Ribosomal, 16SAnti-Bacterial AgentsRNA, Ribosomal, 16S

Identifiers

PMID30944304
PMCPMC6447568
OpenAlexW2929655635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.