Evidence map›Paper›PMID 30944208›Full record

ArticleMolecular pharmacology2019

An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury.

Yunqi An, Pengcheng Wang, Pengfei Xu, Hung-Chun Tung, Yang Xie, Levent Kirisci, Meishu Xu, Songrong Ren, Xin Tian, Xiaochao Ma and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Role of Sulfotransferases in Liver Diseases.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Yunqi AnCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Pengcheng WangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Pengfei XuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Hung-Chun TungCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Yang XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Levent KirisciCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Meishu XuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Songrong RenCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Xin TianCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Xiaochao MaCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.).
Wen XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, (Y.A., P.W., P.X., H-C.T., Y.X., L.K., M.X., S.R., X.T., X.M., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (X.T.) wex6@pitt.edu.
First Affiliated Hospital of Zhengzhou University · CNX-Fab (Germany) · DEUniversity of Pittsburgh · US

Funding

The AHR-FGF221 Axis in Hepatic Steatosis and Metobolic SyndromeR01DK083952 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2010 to 2019
$3.0M
A Novel Regulation of the Phase II Enzyme Estrogen SulfotransferaseR01ES023438 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2014 to 2018
$1.7M
PXR-Mediated Xenobiotic Response in the Pathogenesis Hemorrhagic ShockR01DK117370 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2019 to 2022
$1.4M
NIDDK NIH HHS R01 DK083952NIDDK NIH HHS R01 DK117370NIEHS NIH HHS R01 ES023438
6 · The paper itself

Abstract

Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United States. The sulfotransferase-mediated sulfation of APAP is widely believed to be a protective mechanism to attenuate the hepatotoxicity of APAP. The cholesterol sulfotransferase SULT2B1b is best known for its activity in catalyzing the sulfoconjugation of cholesterol to synthesize cholesterol sulfate. SULT2B1b can be transcriptionally and positively regulated by the hepatic nuclear factor 4

Indexed as

AcetaminophenAnimalsCells, CulturedChemical and Drug Induced Liver Injury, ChronicDisease Models, AnimalDrug OverdoseFemaleHepatocyte Nuclear Factor 4HepatocytesMiceSulfotransferasesAcetaminophenHepatocyte Nuclear Factor 4Hnf4a protein, mouseSulfotransferasesSULT2B1b protein, mouse

Identifiers

PMID30944208
PMCPMC6491915
OpenAlexW2933772595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.