Evidence map›Paper›PMID 30944205›Full record

ArticleBioscience reports2019

One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm.

Ya Wang, Yinchuan Xu, Congqing Wu, Hongguang Xia, Yingchao Wang, Jinliang Nan, Jinghai Chen, Hong Yu, Wei Zhu, Peng Shi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 61 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ya WangDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Yinchuan XuDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Congqing WuSaha Cardiovascular Research Center, University of Kentucky, Lexington, KY, U.S.A.
Hongguang XiaDepartment of Biochemistry and Molecular Biology, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China.
Yingchao WangDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Jinliang NanDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Jinghai ChenDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Hong YuDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Wei ZhuDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Peng ShiDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Alan DaughertySaha Cardiovascular Research Center, University of Kentucky, Lexington, KY, U.S.A.
Hong S LuSaha Cardiovascular Research Center, University of Kentucky, Lexington, KY, U.S.A.
Jian'an WangDepartment of Cardiology, The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China wangjianan111@zju.edu.cn.ORCID 0000-0002-4583-3204
Second Affiliated Hospital of Zhejiang University · CNUniversity of Kentucky · USZhejiang University · CN

Funding

Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
Atherosclerosis Mechanisms: Angiotensin II production and actionR01HL139748 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN, LU, HONG SHEN · 2018 to 2021
$2.0M
Macrophage Pyroptosis in Abdominal Aortic AneurysmK99HL145117 · NHLBI · UNIVERSITY OF KENTUCKY · PI WU, CONGQING · 2019 to 2020
$313k
NHLBI NIH HHS K99 HL145117NHLBI NIH HHS R01 HL133723NHLBI NIH HHS R01 HL139748
6 · The paper itself

Abstract

Angiotensin (Ang) A is formed by the decarboxylation of the N terminal residue of AngII. The present study determined whether this one amino acid change impacted effects of AngII on abdominal aortic aneurysm (AAA) formation in mice. Computational analyses implicated that AngA had comparable binding affinity to both AngII type 1 and 2 receptors as AngII. To compare effects of these two octapeptides

Indexed as

Angiotensin IIMutation, MissenseAmino Acid SubstitutionAnimalsAortic Aneurysm, AbdominalMiceMice, Knockout, ApoEAngiotensin IIangiotensin Aangiotensin IIaortic aneurysmshypercholesterolemiaknockout mice

Identifiers

PMID30944205
PMCPMC6500891
OpenAlexW2930546151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.