Evidence map›Paper›PMID 30944200›Full record

SynthesisJournal of clinical microbiology2019

Diagnostic Accuracy of Stool Xpert MTB/RIF for Detection of Pulmonary Tuberculosis in Children: a Systematic Review and Meta-analysis.

Emily MacLean, Giorgia Sulis, Claudia M Denkinger, James C Johnston, Madhukar Pai, Faiz Ahmad Khan

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 11 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 11 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  9. Evaluating the efficacy of stool sample on Xpert MTB/RIF Ultra and its comparison with other sample types by meta-analysis for TB diagnostics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
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  15. Stool Processing Methods for Xpert Ultra Testing in Childhood Tuberculosis: A Prospective, Multicountry Accuracy Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Emily MacLeanDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.ORCID 0000-0001-9272-0985
Giorgia SulisDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.
Claudia M DenkingerMcGill International TB Centre, McGill University, Montreal, Canada.
James C JohnstonMcGill International TB Centre, McGill University, Montreal, Canada.
Madhukar PaiDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.
Faiz Ahmad KhanDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada faiz.ahmadkhan@mcgill.ca.
McGill University · CAFIND · CHMcGill University Health Centre · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive collection methods are often required to obtain samples for the microbiological evaluation of children with presumptive pulmonary tuberculosis (PTB). Nucleic acid amplification testing of easier-to-collect stool samples could be a noninvasive method of diagnosing PTB. We conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of testing stool with the Xpert MTB/RIF assay ("stool Xpert") for childhood PTB. Four databases were searched for publications from January 2008 to June 2018. Studies assessing the diagnostic accuracy among children of stool Xpert compared to a microbiological reference standard of conventional specimens tested by mycobacterial culture or Xpert were eligible. Bivariate random-effects meta-analyses were performed to calculate pooled sensitivity and specificity of stool Xpert against the reference standard. From 1,589 citations, 9 studies (

Indexed as

Microbial Sensitivity TestsNucleic Acid Amplification TechniquesAdolescentAge FactorsChildChild, PreschoolFecesHumansInfantInfant, NewbornMycobacterium tuberculosisPublication BiasReference ValuesReproducibility of ResultsRifampinSensitivity and SpecificityRifampinchildhood TBpediatric infectious diseasepulmonary tuberculosisstoolXpert MTB/RIF assay

Identifiers

PMID30944200
PMCPMC6535592
OpenAlexW2930734343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.